Inhibition of Enterovirus 71 Shenzhen/120F1/09 capsid infected in human RD cells assessed as reduction in virus-induced cell death after 72 hrs by CCK-8 assay
Antiviral activity against EV71 695F infected in ICR mouse assessed as protection against viral infection by measuring mouse survival at 10 mg/kg, ip qd administered for 7 days dosed prior to viral infection measured for 2 weeks relative to control
Antiviral activity against EV71 695F infected in ICR mouse assessed as protection against viral infection by measuring mouse survival at 10 mg/kg, ip qd administered for 7 days dosed after viral infection measured for 2 weeks relative to control
Antiviral activity against EV71 695F infected in ICR mouse assessed as decrease in body weight loss at 10 mg/kg, ip qd administered for 7 days dosed prior to viral infection measured for 2 weeks
Antiviral activity against EV71 695F infected in ICR mouse assessed as decrease in body weight loss at 10 mg/kg, ip qd administered for 7 days dosed after viral infection measured for 2 weeks
Antiviral activity against EV71 695F infected in ICR mouse assessed as effect on clinical score at 10 mg/kg, ip qd administered for 7 days dosed prior to viral infection measured for 2 weeks
Antiviral activity against EV71 695F infected in ICR mouse assessed as effect on clinical score at 10 mg/kg, ip qd administered for 7 days dosed after viral infection measured for 2 weeks