| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4195026 | F | Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of EC80 glutamate-induced Ca2+ mobilization by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 25 | ALA4190386 | cell-based format | Scientific Literature | |
| 2. | ALA4195027 | F | Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as EC80 glutamate-induced maximum Ca2+ mobilization response at 30 uM relative to 100 uM glutamate by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 18 | ALA4190386 | cell-based format | Scientific Literature | |
| 3. | ALA4195028 | A | Drug metabolism in rat whole blood assessed as 6-(hydroxy(pyridin-3-yl)methyl)-N-(4-methylthiazol-2-yl)quinoline-8-carboxamide formation at 37 degC incubated for 1 hr | Rattus norvegicus | 1 | ALA4190386 | tissue-based format | Scientific Literature | |
| 4. | ALA4195030 | A | Half life in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 5. | ALA4195031 | A | Mean residence time in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 6. | ALA4195032 | A | Plasma clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 7. | ALA4195033 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 8. | ALA4195034 | A | Half life in rat assessed as 6-(hydroxy(pyridin-3-yl)methyl)-N-(4-methylthiazol-2-yl)quinoline-8-carboxamide formation at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 9. | ALA4195035 | A | Mean residence time in rat assessed as 6-(hydroxy(pyridin-3-yl)methyl)-N-(4-methylthiazol-2-yl)quinoline-8-carboxamide formation at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 10. | ALA4195036 | A | Plasma clearance in rat assessed as 6-(hydroxy(pyridin-3-yl)methyl)-N-(4-methylthiazol-2-yl)quinoline-8-carboxamide formation at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature | |
| 11. | ALA4195037 | A | Volume of distribution at steady state in rat assessed as 6-(hydroxy(pyridin-3-yl)methyl)-N-(4-methylthiazol-2-yl)quinoline-8-carboxamide formation at 1 mg/kg, iv | Rattus norvegicus | 1 | ALA4190386 | organism-based format | Scientific Literature |
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