| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4178614 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in formation of midazolam to 1-Hydroxy midazolam at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 2. | ALA4178615 | A | Inhibition of CYP1A2 in human liver microsomes assessed as reduction in formation of phenacetin to acetaminophen at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 3. | ALA4178616 | A | Inhibition of CYP2C9 in human liver microsomes assessed as reduction in formation of tolbutamide to 4-Hydroxytolbutamide at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 4. | ALA4178617 | A | Inhibition of CYP2C19 in human liver microsomes assessed as reduction in formation of mephenytoin to 4-Hydroxy mephenytoin at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 5. | ALA4178618 | A | Inhibition of CYP2D6 in human liver microsomes assessed as reduction in formation of dextromethorphan to dextrorphan at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 6. | ALA4178619 | A | Inhibition of CYP2E1 in human liver microsomes assessed as reduction in formation of chlorzoxazone to 6-Hydroxy chlorzoxazone at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of NADPH by UPLC-MS analysis | Homo sapiens | 5 | microsome format | Scientific Literature | ||
| 7. | ALA4178621 | A | Inhibition of CYP3A4 in human liver microsomes assessed as reduction in formation of midazolam to 1-Hydroxy midazolam at 50 uM preincubated for 30 mins followed by substrate addition measured after 15 mins in presence of varying levels of NADPH by UPLC-MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 8. | ALA4178624 | A | Drug metabolism in human liver microsomes assessed as CYP3A4-mediated metabolite formation at 50 mM preincubated for 5 mins followed by NADPH addition measured after 2 hrs by UPLC-MS/MS analysis | Homo sapiens | 2 | microsome format | Scientific Literature |
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