# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4198189 | B | Inhibition of N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain expressed in Baculovirus infected Sf9 insect cells using FAM-cGMP as substrate after 1 hr by fluorescence polarization assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
2. | ALA4198190 | B | Selectivity ratio of IC50 for N-terminal GST-tagged full length recombinant human PDE1A to IC50 for N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain | Homo sapiens | 16 | assay format | Scientific Literature | ||
3. | ALA4198191 | B | Selectivity ratio of IC50 for N-terminal FLAG-tagged human PDE2A1 (2 to 941 residues) to IC50 for N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain | Homo sapiens | 16 | assay format | Scientific Literature | ||
4. | ALA4198192 | B | Selectivity ratio of IC50 for N-terminal GST-tagged recombinant human PDE3B (592 end residues) to IC50 for N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain | Homo sapiens | 16 | assay format | Scientific Literature | ||
5. | ALA4198193 | B | Selectivity ratio of IC50 for N-terminal GST-tagged full length recombinant human PDE4A1A to IC50 for N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain | Homo sapiens | 16 | assay format | Scientific Literature | ||
6. | ALA4198194 | B | Selectivity ratio of IC50 for N-terminal GST-tagged full length recombinant human PDE6C to IC50 for N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain | Homo sapiens | 18 | assay format | Scientific Literature | ||
7. | ALA4198195 | B | Selectivity ratio of IC50 for N-terminal GST-tagged full length recombinant human PDE11A to IC50 for N-terminal GST-tagged full length recombinant human PDE5A1 catalytic domain | Homo sapiens | 18 | assay format | Scientific Literature | ||
8. | ALA4198220 | F | Vasorelaxant activity in norepinephrine-pretreated New Zealand rabbit thoracic aorta assessed as increase in aortic relaxation at 10 uM measured after 15 mins relative to control | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
9. | ALA4198222 | B | Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrate after 1 hr by fluorescence polarization assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
10. | ALA4198223 | B | Inhibition of N-terminal GST-tagged full length recombinant human PDE11A expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrate after 1 hr by fluorescence polarization assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
11. | ALA4198226 | B | Inhibition of N-terminal GST-tagged full length recombinant human PDE1A expressed in Baculovirus infected Sf9 insect cells at 250 uM using FAM-cAMP as substrate after 1 hr by fluorescence polarization assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4198234 | B | Inhibition of N-terminal FLAG-tagged human PDE2A1 (2 to 941 residues) expressed in Baculovirus infected Sf9 insect cells at 40 uM using FAM-cAMP as substrate after 1 hr by fluorescence polarization assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4198241 | B | Inhibition of N-terminal GST-tagged recombinant human PDE3B (592 end residues) expressed in Baculovirus infected Sf9 insect cells at 250 uM using FAM-cAMP as substrate after 1 hr by fluorescence polarization assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4198247 | B | Inhibition of N-terminal GST-tagged full length recombinant human PDE4A1A expressed in Baculovirus infected Sf9 insect cells at 50 uM using FAM-cAMP as substrate after 1 hr by fluorescence polarization assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |