# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4190815 | Functional | Cytotoxicity against human LN18 cells harboring TP53 mutation assessed as cell death at 20 uM after 48 hrs by MTT assay relative to control | Homo sapiens | 16 | ALA4190186 | cell-based format | Scientific Literature | |
2. | ALA4190816 | Functional | Cytotoxicity against human NCI-H460 cells | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
3. | ALA4190817 | Functional | Cytotoxicity against PTEN/TP53 deficient human T98G cells assessed as cell death at 20 uM after 48 hrs by MTT assay relative to control | Homo sapiens | 16 | ALA4190186 | cell-based format | Scientific Literature | |
4. | ALA4190818 | Functional | Cytotoxicity against human LN18 cells harboring TP53 mutation after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
5. | ALA4190819 | Functional | Cytotoxicity against PTEN/TP53 deficient human T98G cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
6. | ALA4190820 | Functional | Induction of apoptosis in human LN18 cells harboring TP53 mutation assessed as increase in cleaved caspase-3 expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
7. | ALA4190821 | Functional | Induction of apoptosis in PTEN/TP53 deficient human T98G cells assessed as increase in cleaved caspase-3 expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
8. | ALA4190822 | Functional | Induction of apoptosis in human LN18 cells harboring TP53 mutation assessed as increase in cleaved caspase-8 expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
9. | ALA4190823 | Functional | Induction of apoptosis in PTEN/TP53 deficient human T98G cells assessed as increase in cleaved caspase-8 expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
10. | ALA4190824 | Functional | Induction of apoptosis in human LN18 cells harboring TP53 mutation assessed as increase in cleaved caspase-9 expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
11. | ALA4190825 | Functional | Induction of apoptosis in PTEN/TP53 deficient human T98G cells assessed as increase in cleaved caspase-9 expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
12. | ALA4190826 | Functional | Induction of apoptosis in human LN18 cells harboring TP53 mutation assessed as increase in cleaved PARP expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
13. | ALA4190827 | Functional | Induction of apoptosis in PTEN/TP53 deficient human T98G cells assessed as increase in cleaved PARP expression at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
14. | ALA4190828 | Binding | Inhibition of HDAC in human LN18 cells harboring TP53 mutation assessed as increase in H4Ac level at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
15. | ALA4190829 | Binding | Inhibition of HDAC in PTEN/TP53 deficient human T98G cells assessed as increase in H4Ac level at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
16. | ALA4190830 | ADME | Effect on H3K27me3 levels in human LN18 cells harboring TP53 mutation at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature | |
17. | ALA4190831 | ADME | Effect on H3K27me3 levels in PTEN/TP53 deficient human T98G cells at 20 uM after 24 to 48 hrs by Western blot analysis | Homo sapiens | 3 | ALA4190186 | cell-based format | Scientific Literature |