| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4195024 | F | Negative allosteric modulation of human mGlu5 receptor expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization at 10 uM by Fluo-4--AM dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4195025 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 3. | ALA4195026 | F | Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of EC80 glutamate-induced Ca2+ mobilization by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 25 | cell-based format | Scientific Literature | ||
| 4. | ALA4195027 | F | Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as EC80 glutamate-induced maximum Ca2+ mobilization response at 30 uM relative to 100 uM glutamate by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 18 | cell-based format | Scientific Literature | ||
| 5. | ALA4195038 | A | Metabolic stability in human hepatic S9 fraction assessed as intrinsic clearance in presence of NADPH incubated for 60 mins by LC/MS analysis | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 6. | ALA4195039 | A | Metabolic stability in human hepatic S9 fraction assessed as intrinsic clearance in absence of of NADPH incubated for 60 mins by LC/MS analysis | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 7. | ALA4195040 | A | Metabolic stability in human hepatic S9 fraction assessed as NADPH dependent metabolism incubated for 60 mins by LC/MS analysis | Homo sapiens | 2 | subcellular format | Scientific Literature | ||
| 8. | ALA4195041 | A | Metabolic stability in rat hepatic S9 fraction assessed as intrinsic clearance in presence of NADPH incubated for 60 mins by LC/MS analysis | Rattus norvegicus | 2 | subcellular format | Scientific Literature | ||
| 9. | ALA4195042 | A | Metabolic stability in rat hepatic S9 fraction assessed as intrinsic clearance in absence of NADPH incubated for 60 mins by LC/MS analysis | Rattus norvegicus | 2 | subcellular format | Scientific Literature | ||
| 10. | ALA4195043 | A | Metabolic stability in rat hepatic S9 fraction assessed as NADPH dependent metabolism incubated for 60 mins by LC/MS analysis | Rattus norvegicus | 2 | subcellular format | Scientific Literature | ||
| 11. | ALA4195044 | F | Negative allosteric modulation of rat mGlu2 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux at 10 uM preincubated for 5 mins followed by glutamate addition measured after 2 mins by BTC-AM-dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4195045 | F | Negative allosteric modulation of rat mGlu3 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux at 10 uM preincubated for 5 mins followed by glutamate addition measured after 2 mins by BTC-AM-dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4195046 | F | Negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux at 10 uM preincubated for 5 mins followed by glutamate addition measured after 2 mins by BTC-AM-dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4195047 | F | Negative allosteric modulation of rat mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux at 10 uM preincubated for 5 mins followed by glutamate addition measured after 2 mins by BTC-AM-dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4195048 | F | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring GIRK assessed as reduction in L-AP4-induced thallium flux at 10 uM preincubated for 5 mins followed by glutamate addition measured after 2 mins by BTC-AM-dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4195049 | F | Negative allosteric modulation of rat mGlu8 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux at 10 uM preincubated for 5 mins followed by glutamate addition measured after 2 mins by BTC-AM-dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4195050 | F | Negative allosteric modulation of rat mGlu1 receptor expressed in HEK293 cells assessed as reduction in glutamate-induced calcium mobilization at 10 uM preincubated for 2.3 mins followed by glutamate addition measured after 2.6 mins by Fluo-4--AM dye based fluorescence assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4195051 | B | Selectivity ratio of compound effect for negative allosteric modulation of rat mGlu2 receptor expressed in HEK cells harboring GIRK to compound effect for negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4195052 | B | Selectivity ratio of compound effect for negative allosteric modulation of rat mGlu3 receptor expressed in HEK cells harboring GIRK to compound effect for negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4195053 | B | Selectivity ratio of compound effect for negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK to compound effect for negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells | Rattus norvegicus | 3 | cell-based format | Scientific Literature |
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