# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4189919 | B | Agonist activity at recombinant human 5-HT4E receptor expressed in CHO cells assessed as induction of c-AMP accumulation after 4 hrs by luciferase reporter assay | Homo sapiens | 47 | ALA4184335 | cell-based format | Scientific Literature | |
2. | ALA4189920 | B | Agonist activity at recombinant human 5-HT4E receptor expressed in CHO cells assessed as induction of c-AMP accumulation after 4 hrs by luciferase reporter assay relative to 5-HT | Homo sapiens | 42 | ALA4184335 | cell-based format | Scientific Literature | |
3. | ALA4189921 | A | Drug metabolism in rat liver microsomes after 30 mins by LC-MS/MS method | Rattus norvegicus | 47 | ALA4184335 | microsome format | Scientific Literature | |
4. | ALA4189922 | A | Drug metabolism in human liver microsomes after 30 mins by LC-MS/MS method | Homo sapiens | 47 | ALA4184335 | microsome format | Scientific Literature | |
5. | ALA4189923 | A | Oral bioavailability in Wistar rat at 3 mg/kg by LC-MS/MS method | Rattus norvegicus | 47 | ALA4184335 | organism-based format | Scientific Literature | |
6. | ALA4189924 | A | Cmax in Wistar rat at 3 mg/kg, po or 1 mg/kg, iv by LC-MS/MS method | Rattus norvegicus | 47 | ALA4184335 | organism-based format | Scientific Literature | |
7. | ALA4189925 | A | AUC in Wistar rat at 3 mg/kg, po or 1 mg/kg, iv by LC-MS/MS method | Rattus norvegicus | 47 | ALA4184335 | organism-based format | Scientific Literature | |
8. | ALA4189926 | A | Clearance in Wistar rat at 1 mg/kg, iv by LC-MS/MS method | Rattus norvegicus | 47 | ALA4184335 | organism-based format | Scientific Literature | |
9. | ALA4189927 | A | Ratio of drug level in Wistar rat brain to plasma at 10 mg/kg, po measured at 1 hr by LC-MS/MS method | Rattus norvegicus | 47 | ALA4184335 | organism-based format | Scientific Literature | |
10. | ALA4189929 | F | Cognition enhancing effect in Wistar rat assessed as increase in time spent exploring novel object over familiar object at 3 to 10 mg/kg, po administered 30 mins prior to training measured after 24 hrs by novel object recognition assay | Rattus norvegicus | 1 | ALA4184335 | organism-based format | Scientific Literature | |
11. | ALA4189932 | F | Cognition enhancing effect in Wistar rat assessed as increase in time spent exploring novel object over familiar object at 3 mg/kg, po administered 30 mins prior to training measured after 24 hrs in presence of 5-HT4R antagonist GR-125487 by novel object recognition assay | Rattus norvegicus | 1 | ALA4184335 | organism-based format | Scientific Literature | |
12. | ALA4189933 | F | In vivo receptor occupancy at 5-HT4 receptor in po dosed Wistar rat striatum assessed as decrease in SB207145 binding after 1 hr by LC-MS/MS method | Rattus norvegicus | 4 | ALA4184335 | organism-based format | Scientific Literature | |
13. | ALA4189935 | A | Fraction unbound in rat plasma at 1 uM after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4184335 | cell-free format | Scientific Literature | |
14. | ALA4189936 | A | Fraction unbound in rat brain at 1 uM after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4184335 | tissue-based format | Scientific Literature | |
15. | ALA4189937 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 2 mins in presence of NADPH-regeneration system by LC-MS/MS method | Homo sapiens | 2 | ALA4184335 | microsome format | Scientific Literature | |
16. | ALA4189938 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 12 mins in presence of NADPH-regeneration system by LC-MS/MS method | Homo sapiens | 2 | ALA4184335 | microsome format | Scientific Literature | |
17. | ALA4189939 | F | Cognition enhancing effect in po dosed Wistar rat assessed as increase in synaptic release of acetylcholine in brain after 4 hrs by microdialysis method | Rattus norvegicus | 1 | ALA4184335 | organism-based format | Scientific Literature | |
18. | ALA4189942 | F | In vivo partial agonist activity at 5-HT4 receptor in C57BL/6J mouse assessed as increase in cortical sAPPalpha levels at 1 to 10 mg/kg, sc after 60 to 90 mins by ELISA relative to control | Mus musculus | 1 | ALA4184335 | organism-based format | Scientific Literature | |
19. | ALA4189943 | B | Agonist activity at recombinant human 5-HT4D receptor expressed in CHO cells assessed as induction of c-AMP accumulation after 4 hrs by luciferase reporter assay | Homo sapiens | 2 | ALA4184335 | cell-based format | Scientific Literature | |
20. | ALA4189944 | B | Agonist activity at recombinant rat 5-HT4L receptor expressed in CHO cells assessed as induction of c-AMP accumulation after 4 hrs by luciferase reporter assay | Rattus norvegicus | 2 | ALA4184335 | cell-based format | Scientific Literature |