# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4201103 | Binding | Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Mycobacterium tuberculosis H37Rv | 13 | ALA4196176 | assay format | Scientific Literature | |
2. | ALA4201104 | Binding | Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpA expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Mycobacterium tuberculosis H37Rv | 8 | ALA4196176 | assay format | Scientific Literature | |
3. | ALA4201105 | Binding | Inhibition of human PTP1B using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Homo sapiens | 10 | ALA4196176 | single protein format | Scientific Literature | |
4. | ALA4201106 | Binding | Inhibition of human VHR using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Homo sapiens | 8 | ALA4196176 | single protein format | Scientific Literature | |
5. | ALA4201108 | Binding | Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB H94A mutant expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Mycobacterium tuberculosis H37Rv | 5 | ALA4196176 | assay format | Scientific Literature | |
6. | ALA4201109 | Binding | Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB E129A mutant expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Mycobacterium tuberculosis H37Rv | 5 | ALA4196176 | assay format | Scientific Literature | |
7. | ALA4201110 | Binding | Inhibition of Mycobacterium tuberculosis H37Rv His-tagged ptpB R136A mutant expressed in Escherichia coli BL21(DE3) using pNPP as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins | Mycobacterium tuberculosis H37Rv | 5 | ALA4196176 | assay format | Scientific Literature | |
8. | ALA4201123 | ADME | Cmax in Dunkin Hartley guinea pig at 2.5 mg/kg, ip after 0.5 hrs post dose | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature | |
9. | ALA4201124 | ADME | Half life in Dunkin Hartley guinea pig at 2.5 mg/kg, ip | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature | |
10. | ALA4201125 | ADME | AUCinfinity in Dunkin Hartley guinea pig at 2.5 mg/kg, ip | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature | |
11. | ALA4201126 | ADME | Cmax in Dunkin Hartley guinea pig at 5 mg/kg, po after 0.25 hrs post dose | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature | |
12. | ALA4201127 | ADME | Half life in Dunkin Hartley guinea pig at 5 mg/kg, po | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature | |
13. | ALA4201128 | ADME | AUCinfinity in Dunkin Hartley guinea pig at 5 mg/kg, po | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature | |
14. | ALA4201129 | ADME | Oral bioavailability in Dunkin Hartley guinea pig at 5 mg/kg | Cavia porcellus | 2 | ALA4196176 | organism-based format | Scientific Literature |