# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4201411 | F | Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures by PicoGreen dye based assay | Plasmodium falciparum | 18 | organism-based format | Scientific Literature | ||
2. | ALA4201412 | A | Effect on DXR protein level in Plasmodium falciparum 3D7 at 5 times growth inhibitory IC50 incubated for 10 hrs by LC-MS/MS method | Plasmodium falciparum | 1 | organism-based format | Scientific Literature | ||
3. | ALA4201413 | A | Cytotoxicity in human HepG2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4201414 | T | Selectivity index, ratio of IC50 for cytotoxicity in human HepG2 cells to IC50 for growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures | 2 | cell-based format | Scientific Literature | |||
5. | ALA4201415 | A | Half life in mouse liver microsomes | Mus musculus | 2 | microsome format | Scientific Literature | ||
6. | ALA4201416 | A | Half life in mouse plasma | Mus musculus | 2 | cell-free format | Scientific Literature | ||
7. | ALA4201417 | F | Growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures at 0.01 to 100 uM incubated for 72 hrs in presence of excess IPP by PicoGreen dye based assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
8. | ALA4201418 | B | Inhibition of DXR in Plasmodium falciparum 3D7 assessed as reduction in MEP levels at 5 times growth inhibitory IC50 incubated for 10 hrs by LC-MS/MS method | Plasmodium falciparum 3D7 | 1 | single protein format | Scientific Literature | ||
9. | ALA4201419 | B | Inhibition of DXR in Plasmodium falciparum 3D7 assessed as reduction in CDP-ME levels at 5 times growth inhibitory IC50 incubated for 10 hrs by LC-MS/MS method | Plasmodium falciparum 3D7 | 1 | single protein format | Scientific Literature | ||
10. | ALA4201420 | B | Inhibition of DXR in Plasmodium falciparum 3D7 assessed as reduction in MEcPP levels at 5 times growth inhibitory IC50 incubated for 10 hrs by LC-MS/MS method | Plasmodium falciparum 3D7 | 1 | single protein format | Scientific Literature | ||
11. | ALA4201421 | F | Resistance index, ratio of IC50 for Plasmodium falciparum containing had1 mutation to IC50 for growth inhibition of wild type Plasmodium falciparum 3D7 asynchronous cultures | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
12. | ALA4201422 | F | Growth inhibition of Plasmodium falciparum containing had1 mutation expressing GFP-HAD1 by PicoGreen dye based assay | Plasmodium falciparum | 2 | organism-based format | Scientific Literature | ||
13. | ALA4201425 | F | Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA infected in Swiss Webster mouse assessed as reduction in parasitemia by measuring reduction in luciferin signal intensity at 20 mg/kg, ip administered daily for 5 days starting from 2 days post infection by luciferase-luciferin based reporter assay relative to untreated control | Plasmodium berghei | 1 | organism-based format | Scientific Literature | ||
14. | ALA4201426 | F | Antimalarial activity against luciferase-expressing Plasmodium berghei ANKA infected in Swiss Webster mouse assessed as reduction in parasitemia by measuring reduction in luciferin signal intensity at 50 mg/kg, ip administered daily for 5 days starting from 2 days post infection by luciferase-luciferin based reporter assay relative to untreated control | Plasmodium berghei | 1 | organism-based format | Scientific Literature | ||
15. | ALA4201427 | T | Toxicity in luciferase-expressing Plasmodium berghei ANKA infected Swiss Webster mouse assessed as induction of adverse events at 20 mg/kg, ip administered daily for 5 days starting from 2 days post infection | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4201428 | T | Toxicity in luciferase-expressing Plasmodium berghei ANKA infected Swiss Webster mouse assessed as induction of adverse events at 50 mg/kg, ip administered daily for 5 days starting from 2 days post infection | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4201429 | A | Drug metabolism in Swiss Webster mouse assessed as plasma concentration of sodium hydrogen [(1E)-3-(N-hydroxyformamido)prop-1-en-1-yl]phosphonate at 20 mg/kg, ip measured over 8 hrs post dose by LC-MS/MS method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4201430 | A | Ratio of drug metabolism in Swiss Webster mouse assessed as plasma concentration of sodium hydrogen [(1E)-3-(N-hydroxyformamido)prop-1-en-1-yl]phosphonate at 20 mg/kg, ip measured over 8 hrs post dose by LC-MS/MS method to IC50 for growth inhibition of Plasmodium falciparum 3D7 asynchronous cultures | 1 | organism-based format | Scientific Literature |