| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4184958 | B | Inhibition of mouse CHIT1 using 4-methylumbelliferyl beta-D-N,N',N'' triacetylchitotrioside as substrate measured after 60 mins by fluorometric method | Mus musculus | 20 | ALA4184114 | single protein format | Scientific Literature | |
| 2. | ALA4184959 | B | Inhibition of mouse AMCase using 4-methylumbelliferyl beta-D-N,N' diacetylchitobioside hydrate as substrate measured after 60 mins by fluorometric method | Mus musculus | 20 | ALA4184114 | single protein format | Scientific Literature | |
| 3. | ALA4184960 | B | Selectivity ratio of IC50 for mouse CHIT1 to IC50 for mouse AMCase | Mus musculus | 20 | ALA4184114 | assay format | Scientific Literature | |
| 4. | ALA4184961 | A | AUC (0 to infinity) in BALB/c mouse at 3 mg/kg, iv administered as bolus dose by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 5. | ALA4184962 | A | Cmax in BALB/c mouse at 3 mg/kg, iv administered as bolus dose by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 6. | ALA4184963 | A | Clearance in BALB/c mouse at 3 mg/kg, iv administered as bolus dose by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 7. | ALA4184964 | A | Volume of distribution at steady state in BALB/c mouse at 3 mg/kg, iv administered as bolus dose by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 8. | ALA4184965 | A | Half-life in BALB/c mouse at 3 mg/kg, iv administered as bolus dose by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 9. | ALA4184966 | A | AUC (0 to infinity) in BALB/c mouse at 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 10. | ALA4184967 | A | Cmax in BALB/c mouse at 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 11. | ALA4184968 | A | Tmax in BALB/c mouse at 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 12. | ALA4184969 | A | Half-life in BALB/c mouse at 10 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 13. | ALA4184970 | A | Oral bioavailability in BALB/c mouse at 10 mg/kg by LC-MS/MS analysis | Mus musculus | 1 | ALA4184114 | organism-based format | Scientific Literature | |
| 14. | ALA4704014 | B | Inhibition of full-length C-terminal his-tagged human recombinant CHIT1 catalytic domain (1 to 386 residues) expressed in HEK293F cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N',N"-triacetylchitotrioside as substrate after 60 mins by fluorometric assay | Homo sapiens | 18 | ALA4699582 | cell-based format | Scientific Literature | |
| 15. | ALA4704015 | B | Inhibition of recombinant full-length C-terminal his-tagged mouse CHIT1 expressed in CHO-K1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N',N"-triacetylchitotrioside as substrate after 60 mins by fluorometric assay | Mus musculus | 18 | ALA4699582 | cell-based format | Scientific Literature | |
| 16. | ALA4704017 | B | Inhibition of full-length C-terminal his-tagged human AMCase expressed in CHO-K1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N-diacetylchitobioside hydrate as substrate after 60 mins by fluorometric assay | Homo sapiens | 18 | ALA4699582 | cell-based format | Scientific Literature | |
| 17. | ALA4704018 | B | Inhibition of full-length C-terminal his-tagged mouse AMCase expressed in expressed in CHO-K1 cells assessed as reduction in chitinolytic activity using 4-methylumbelliferyl-beta-D-N,N'-diacetylchitobioside hydrate as substrate after 60 mins by fluorometric assay | Mus musculus | 18 | ALA4699582 | cell-based format | Scientific Literature | |
| 18. | ALA4704019 | B | Inhibition of tracer red binding to human ERG expressed in HEK293 cell membranes measured after 2 to 6 hrs by fluorescence polarization assay | Homo sapiens | 18 | ALA4699582 | cell membrane format | Scientific Literature | |
| 19. | ALA4704020 | B | Inhibition of [3H]BTCP binding to human recombinant dopamine transporter at 10 uM measured after 120 mins by scintillation counting method relative to control | Homo sapiens | 18 | ALA4699582 | single protein format | Scientific Literature |
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