# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4188130 | F | Growth inhibition of human A549 cells incubated for 6 days in presence of 400 U/ml IFNalpha by MTS assay | Homo sapiens | 4 | ALA4184246 | cell-based format | Scientific Literature | |
2. | ALA4188131 | F | Growth inhibition of human A549 cells incubated for 6 days in absence of 400 U/ml IFNalpha by MTS assay | Homo sapiens | 4 | ALA4184246 | cell-based format | Scientific Literature | |
3. | ALA4188132 | F | Growth inhibition of human OVCAR3 cells incubated for 7 days in presence of 400 U/ml IFNalpha by MTS assay | Homo sapiens | 4 | ALA4184246 | cell-based format | Scientific Literature | |
4. | ALA4188133 | F | Growth inhibition of human OVCAR3 cells incubated for 7 days in absence of 400 U/ml IFNalpha by MTS assay | Homo sapiens | 4 | ALA4184246 | cell-based format | Scientific Literature | |
5. | ALA4188134 | B | Binding affinity to 14-3-3zeta (unknown origin) assessed as stabilization of protein-protein interaction between 14-3-3zeta and fluorescein-labeled phosphopeptide by measuring Kd of FAM-KRSHpSV-COOH at 40 uM by fluorescence polarization assay (Rvb = 470 +/- 20 nM) | Homo sapiens | 4 | ALA4184246 | single protein format | Scientific Literature | |
6. | ALA4188135 | B | Binding affinity to 14-3-3zeta (unknown origin) assessed as stabilization of protein-protein interaction between 14-3-3zeta and fluorescein-labeled phosphopeptide by measuring reduction in Kd of FAM-KRSHpSV-COOH at 40 uM by fluorescence polarization assay relative to untreated control | Homo sapiens | 4 | ALA4184246 | single protein format | Scientific Literature | |
7. | ALA4188140 | F | Increase in DR5 protein expression in human A549 cells at 13 uM incubated for 4 days in absence of 200 U/ml IFNalpha by Western blot analysis | Homo sapiens | 1 | ALA4184246 | cell-based format | Scientific Literature | |
8. | ALA4188141 | F | Increase in DR5 protein expression in human A549 cells at 13 uM incubated for 4 days in presence of 200 U/ml IFNalpha by Western blot analysis | Homo sapiens | 1 | ALA4184246 | cell-based format | Scientific Literature | |
9. | ALA4188142 | F | Induction of apoptosis in human A549 cells assessed as increase in PARP cleavage at 13 uM incubated for 4 days in absence of 200 U/ml IFNalpha by Western blot analysis | Homo sapiens | 1 | ALA4184246 | cell-based format | Scientific Literature | |
10. | ALA4188143 | F | Induction of apoptosis in human A549 cells assessed as increase in PARP cleavage at 13 uM incubated for 4 days in presence of 200 U/ml IFNalpha by Western blot analysis | Homo sapiens | 1 | ALA4184246 | cell-based format | Scientific Literature | |
11. | ALA4188146 | F | Growth inhibition of human A549 cells at 13 uM incubated for 4 days in presence of 200 U/ml IFNalpha and 30 nM 14-3-3zeta siRNA by MTS assay | Homo sapiens | 1 | ALA4184246 | cell-based format | Scientific Literature | |
12. | ALA4188147 | F | Growth inhibition of human A549 cells at 13 uM incubated for 4 days in presence of 200 U/ml IFNalpha and in absence of 30 nM 14-3-3zeta siRNA by MTS assay | Homo sapiens | 1 | ALA4184246 | cell-based format | Scientific Literature |