# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4178350 | ADME | Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 21 | ALA4177539 | cell-based format | Scientific Literature | |
2. | ALA4178351 | Binding | Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 22 | ALA4177539 | cell-based format | Scientific Literature | |
3. | ALA4178360 | Binding | Inhibition of EGFR T790M/exon 19 deletion mutant phosphorylation in human PC9-DRH cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 10 | ALA4177539 | cell-based format | Scientific Literature | |
4. | ALA4178361 | Binding | Inhibition of EGFR exon 19 deletion mutant phosphorylation in human PC9 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 10 | ALA4177539 | cell-based format | Scientific Literature | |
5. | ALA4178362 | Binding | Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISA | Homo sapiens | 10 | ALA4177539 | cell-based format | Scientific Literature | |
6. | ALA4178363 | Binding | Selectivity index, ratio of IC50 for wild-type EGFR autophosphorylation in human A549 cells to IC50 for EGFR exon 19 deletion mutant autophosphorylation in human PC9 cells | Homo sapiens | 5 | ALA4177539 | cell-based format | Scientific Literature |