# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4185264 | P | Octanol-water partition coefficient, log P of the compound at 1 mg by RP-HPLC analysis | 21 | ALA4184139 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4185265 | F | Cytoprotection against PQ-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM pretreated for 2 hrs followed by 1 mM PQ addition measured after 24 hrs by MTT assay | Homo sapiens | 16 | ALA4184139 | cell-based format | Scientific Literature | |
3. | ALA4185266 | F | Cytoprotection against PQ-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM pretreated for 2 hrs followed by 1 mM PQ addition measured after 24 hrs by LDH assay | Homo sapiens | 16 | ALA4184139 | cell-based format | Scientific Literature | |
4. | ALA4185267 | F | Cytoprotection against H2O2-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM pretreated for 2 hrs followed by 1 mM H2O2 addition measured after 24 hrs by MTT assay | Homo sapiens | 16 | ALA4184139 | cell-based format | Scientific Literature | |
5. | ALA4185268 | F | Cytoprotection against H2O2-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM pretreated for 2 hrs followed by 1 mM H2O2 addition measured after 24 hrs by LDH assay | Homo sapiens | 16 | ALA4184139 | cell-based format | Scientific Literature | |
6. | ALA4185269 | F | Cytoprotection against PQ-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM treated 2 hrs post 2 mM PQ treatment measured after 24 hrs by MTT assay | Homo sapiens | 15 | ALA4184139 | cell-based format | Scientific Literature | |
7. | ALA4185270 | F | Cytoprotection against PQ-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM treated 2 hrs post 2 mM PQ treatment measured after 24 hrs by LDH assay | Homo sapiens | 11 | ALA4184139 | cell-based format | Scientific Literature | |
8. | ALA4185271 | F | Cytoprotection against H2O2-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM treated 2 hrs post 0.8 mM H2O2 treatment measured after 24 hrs by MTT assay | Homo sapiens | 14 | ALA4184139 | cell-based format | Scientific Literature | |
9. | ALA4185272 | F | Cytoprotection against H2O2-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM treated 2 hrs post 0.8 mM H2O2 treatment measured after 24 hrs by LDH assay | Homo sapiens | 11 | ALA4184139 | cell-based format | Scientific Literature | |
10. | ALA4185276 | F | Cytoprotection against PQ-induced cell death in human SK-N-BE(2)-M17 cells assessed as increase in cell viability at 100 uM treated post 200 uM Fecl3 and 1 mM PQ treatment measured after 24 hrs by LDH assay | Homo sapiens | 8 | ALA4184139 | cell-based format | Scientific Literature | |
11. | ALA4185277 | F | Cytoprotection against H2O2-induced cell death in BSO pretreated C57BL6/J mouse brain primary astrocytes assessed as increase in cell viability at 10 uM pretreated for 2 hrs followed by H2O2 addition measured after 24 hrs by MTT assay | Mus musculus | 10 | ALA4184139 | cell-based format | Scientific Literature | |
12. | ALA4185278 | F | Cytoprotection against H2O2-induced cell death in BSO pretreated C57BL6/J mouse brain primary astrocytes assessed as increase in cell viability at 10 uM pretreated for 2 hrs followed by H2O2 addition measured after 24 hrs by LDH release assay | Mus musculus | 8 | ALA4184139 | cell-based format | Scientific Literature | |
13. | ALA4185280 | A | Cytotoxicity against human SK-N-BE(2)-M17 cells at 100 uM 24 hrs by MTT assay | Homo sapiens | 16 | ALA4184139 | cell-based format | Scientific Literature | |
14. | ALA4185281 | A | Cytotoxicity against human SK-N-BE(2)-M17 cells at 100 uM 24 hrs by LDH release assay | Homo sapiens | 16 | ALA4184139 | cell-based format | Scientific Literature | |
15. | ALA4185284 | B | Binding affinity to Fe3+ assessed as [M+H]+ adduct formation by LC-MS/MS analysis | 16 | ALA4184139 | assay format | Scientific Literature | ||
16. | ALA4185285 | B | Binding affinity to Fe3+ assessed as [M+2H]+ adduct formation by LC-MS/MS analysis | 16 | ALA4184139 | assay format | Scientific Literature | ||
17. | ALA4185286 | B | Binding affinity to Fe3+ assessed as change in retention time for compound-Fe3+ complex by RP-HPLC analysis relative to free ligand | 17 | ALA4184139 | assay format | Scientific Literature |