| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4187194 | B | Inhibition of recombinant human full length N-terminal GST-tagged CK1delta expressed in baculovirus in Sf9 insect cells using ULight-Topo-IIa(Thr1342) peptide as substrate after 10 mins by TR-FRET assay | Homo sapiens | 66 | ALA4184198 | cell-based format | Scientific Literature | |
| 2. | ALA4187195 | B | Inhibition of recombinant human full length N-terminal GST-tagged CK1epsilon expressed in baculovirus in Sf9 insect cells using ULight-Topo-IIa(Thr1342) peptide as substrate after 10 mins by TR-FRET assay | Homo sapiens | 66 | ALA4184198 | cell-based format | Scientific Literature | |
| 3. | ALA4187196 | F | Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter-Glo assay | Homo sapiens | 66 | ALA4184198 | cell-based format | Scientific Literature | |
| 4. | ALA4187197 | P | Aqueous solubility of the compound at pH 7.4 measured after 24 hrs by HPLC analysis | 22 | ALA4184198 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4187198 | A | Half life in human liver microsomes at 1 uM by LC/MS analysis | Homo sapiens | 23 | ALA4184198 | microsome format | Scientific Literature | |
| 6. | ALA4187199 | A | Half life in mouse liver microsomes at 1 uM by LC/MS analysis | Mus musculus | 23 | ALA4184198 | microsome format | Scientific Literature | |
| 7. | ALA4187200 | A | Half life in rat liver microsomes at 1 uM by LC/MS analysis | Rattus norvegicus | 23 | ALA4184198 | microsome format | Scientific Literature | |
| 8. | ALA4187201 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate at 10 uM after 10 mins in presence of NADPH relative to control | Homo sapiens | 22 | ALA4184198 | microsome format | Scientific Literature | |
| 9. | ALA4187202 | A | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate at 10 uM after 10 mins in presence of NADPH relative to control | Homo sapiens | 22 | ALA4184198 | microsome format | Scientific Literature | |
| 10. | ALA4187203 | A | Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate at 10 uM after 10 mins in presence of NADPH relative to control | Homo sapiens | 22 | ALA4184198 | microsome format | Scientific Literature | |
| 11. | ALA4187204 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM after 10 mins in presence of NADPH relative to control | Homo sapiens | 22 | ALA4184198 | microsome format | Scientific Literature | |
| 12. | ALA4187207 | A | Cmax in C57BL6 mouse at 20 mg/kg, ip by LC-MS/MS analysis | Mus musculus | 1 | ALA4184198 | organism-based format | Scientific Literature | |
| 13. | ALA4187210 | A | Clearance in C57BL6 mouse at 20 mg/kg, ip up to 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4184198 | organism-based format | Scientific Literature | |
| 14. | ALA4187213 | A | AUC in C57BL6 mouse at 20 mg/kg, ip up to 8 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4184198 | organism-based format | Scientific Literature | |
| 15. | ALA4187216 | A | Half life in C57BL6 mouse at 00 mg/kg, ip by LC-MS/MS analysis | Mus musculus | 1 | ALA4184198 | organism-based format | Scientific Literature | |
| 16. | ALA4187221 | B | Inhibition of human phosphorylated ABL1 E255K mutant (S229 to K512 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4184198 | assay format | Scientific Literature | |
| 17. | ALA4187222 | B | Inhibition of human phosphorylated ABL1 T315I mutant (S229 to K512 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4184198 | assay format | Scientific Literature | |
| 18. | ALA4187223 | B | Inhibition of wild-type human non-phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4184198 | assay format | Scientific Literature | |
| 19. | ALA4187224 | B | Inhibition of wild-type human phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system assessed as residual activity at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4184198 | assay format | Scientific Literature | |
| 20. | ALA4187225 | B | Inhibition of wild-type human ACVR1B (S187 to I505 residues) expressed in bacterial expression system assessed as residual activity at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4184198 | assay format | Scientific Literature |
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