| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4179116 | A | Cytotoxicity in human Friedreich's ataxia lymphocytes assessed as reduction in cell viability at 2.5 uM incubated for 24 hrs by Live/Dead cell viability assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA4179117 | A | Cytotoxicity in human Friedreich's ataxia lymphocytes assessed as reduction in cell viability at 2.5 uM incubated for 48 hrs by Live/Dead cell viability assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 3. | ALA4179118 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye monomer level at 1 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 10.1%) | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA4179119 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye aggregates level at 1 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 69.8%) | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 5. | ALA4179120 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye monomer level at 5 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 10.1%) | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 6. | ALA4179121 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye aggregates level at 5 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 69.8%) | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA4179122 | F | Cytoprotection against buthionine sulfoximine-induced cytotoxicity in human Friedreich's ataxia lymphocytes assessed as increase in cell viability at 25 to 1000 nM pre-incubated before buthionine sulfoximine challenge for 48 hrs by Live/Dead cell viability assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4179123 | F | Inhibition of ROS generation in human Friedreich's ataxia lymphocytes at 250 and 2500 nM incubated for 16 hrs by DCFH-DA staining based FACS method | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA4179124 | F | Cytoprotection against rotenone-induced cytotoxicity in human Friedreich's ataxia lymphocytes assessed as increase in cell viability at 0.25 and 2.5 uM pre-incubated for 12 hrs in glucose-free media followed by rotenone challenge for 24 hrs by Live/Dead cell viability assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 10. | ALA4179125 | B | Effect on NADH-ubiquinone oxidoreductase in bovine heart submitochondrial particles assessed as induction of electron flow from complex-1 by measuring NADH oxidation at 5 uM in presence of 50 nM rotenone using NADH and coenzyme Q1 by spectrophotomery | Bos taurus | 3 | assay format | Scientific Literature | ||
| 11. | ALA4179129 | F | Increase in ATP level in human Friedreich's ataxia lymphocytes at 0.1 uM incubated for 24 hrs by luminescence based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4179130 | F | Increase in ATP level in human Friedreich's ataxia lymphocytes at 0.5 uM incubated for 24 hrs by luminescence based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4179131 | A | Reduction in ATP level in human Friedreich's ataxia lymphocytes at 5 uM incubated for 24 hrs by luminescence based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4260032 | F | Effect on frataxin expression in human GM15850 cells at 50 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA4260033 | F | Effect on frataxin expression in human GM16216 cells at 50 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA4260034 | F | Effect on frataxin expression in human GM15850 cells at 250 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA4260035 | F | Effect on frataxin expression in human GM16216 cells at 250 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4260036 | F | Effect on frataxin expression in human GM15850 cells at 50 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4260037 | F | Effect on frataxin expression in human GM16216 cells at 50 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4260038 | F | Effect on frataxin expression in human GM15850 cells at 250 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature |
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