# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4180102 | F | Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization | Rattus norvegicus | 30 | ALA4177610 | cell-based format | Scientific Literature | |
2. | ALA4180103 | F | Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mobilization relative to acetylcholine | Rattus norvegicus | 24 | ALA4177610 | cell-based format | Scientific Literature | |
3. | ALA4180104 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 4 | ALA4177610 | microsome format | Scientific Literature | |
4. | ALA4180105 | A | Clearance in rat hepatocytes | Rattus norvegicus | 4 | ALA4177610 | cell-based format | Scientific Literature | |
5. | ALA4180106 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 4 | ALA4177610 | microsome format | Scientific Literature | |
6. | ALA4180107 | A | Clearance in human hepatocytes | Homo sapiens | 4 | ALA4177610 | cell-based format | Scientific Literature | |
7. | ALA4180108 | A | Fraction unbound in rat plasma | Rattus norvegicus | 4 | ALA4177610 | cell-free format | Scientific Literature | |
8. | ALA4180109 | A | Fraction unbound in human plasma | Homo sapiens | 4 | ALA4177610 | cell-free format | Scientific Literature | |
9. | ALA4180110 | A | Fraction unbound in rat brain | Rattus norvegicus | 4 | ALA4177610 | tissue-based format | Scientific Literature | |
10. | ALA4180111 | A | Brain to plasma partition coefficient, Kp of the compound in Sprague-Dawley rat at 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 4 | ALA4177610 | organism-based format | Scientific Literature | |
11. | ALA4180112 | A | Ratio of unbound brain to plasma concentration in Sprague-Dawley rat at 0.2 mg/kg, iv measured after 0.25 hrs | Rattus norvegicus | 4 | ALA4177610 | organism-based format | Scientific Literature |