| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4199724 | F | Antagonist activity at human CRTh2 expressed in HEK cells assessed as inhibition of DK-PGD2-mediated attenuation of forskolin-induced intracellular cAMP accumulation preincubated for 10 mins followed by forskolin stimulation measured after 10 to 60 mins by ELISA based chemiluminescence assay | Homo sapiens | 16 | ALA4196118 | cell-based format | Scientific Literature | |
| 2. | ALA4199725 | B | Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting method | Homo sapiens | 45 | ALA4196118 | cell-based format | Scientific Literature | |
| 3. | ALA4199726 | F | Antagonist activity at human CRTh2 expressed in CHOK1 cells assessed as inhibition of PGD2-induced beta-arrestin recruitment incubated for 30 mins followed by PGD2 stimulation measured after 60 mins by PathHunter based chemiluminescence assay | Homo sapiens | 12 | ALA4196118 | cell-based format | Scientific Literature | |
| 4. | ALA4199727 | F | Antagonist activity at CRTh2 in human whole blood assessed as inhibition of DK-PGD2-induced eosinophils shape change preincubated for 10 mins followed by DK-PGD2 addition measured after 4 mins by flow cytometry | Homo sapiens | 12 | ALA4196118 | assay format | Scientific Literature | |
| 5. | ALA4199730 | A | AUC (0 to 6 hrs) in rat at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 6. | ALA4199732 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 1 | ALA4196118 | single protein format | Scientific Literature | |
| 7. | ALA4199733 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 1 | ALA4196118 | single protein format | Scientific Literature | |
| 8. | ALA4199734 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 1 | ALA4196118 | single protein format | Scientific Literature | |
| 9. | ALA4199735 | B | Activation of PXR (unknown origin) | Homo sapiens | 1 | ALA4196118 | single protein format | Scientific Literature | |
| 10. | ALA4199736 | A | Clearance in rat plasma at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 11. | ALA4199737 | A | Clearance in dog plasma at 1 mg/kg, iv | Canis lupus familiaris | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 12. | ALA4199738 | A | Clearance in monkey plasma at 1 mg/kg, iv | Macaca mulatta | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 13. | ALA4199739 | A | Volume of distribution in rat at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 14. | ALA4199740 | A | Volume of distribution in dog at 1 mg/kg, iv | Canis lupus familiaris | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 15. | ALA4199741 | A | Volume of distribution in monkey at 1 mg/kg, iv | Macaca mulatta | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 16. | ALA4199742 | A | Half life in rat at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 17. | ALA4199743 | A | Half life in dog at 1 mg/kg, iv | Canis lupus familiaris | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 18. | ALA4199744 | A | Half life in monkey at 1 mg/kg, iv | Macaca mulatta | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 19. | ALA4199745 | A | AUC in rat at 3 mg/kg, iv | Rattus norvegicus | 1 | ALA4196118 | organism-based format | Scientific Literature | |
| 20. | ALA4199746 | A | AUC in dog at 1 mg/kg, iv | Canis lupus familiaris | 1 | ALA4196118 | organism-based format | Scientific Literature |
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