Displacement of [3H]-8-OH-DPAT from serotonin 5-HT1A receptor in Sprague-Dawley rat brain cortex homogenates incubated for 30 mins by liquid scintillation spectrometry
Displacement of [3H]ketanserin from serotonin 5-HT2A receptor in Sprague-Dawley rat brain cortex homogenates incubated for 15 mins by liquid scintillation spectrometry
Displacement of [3H]mesulergine from serotonin 5-HT2C receptor in Sprague-Dawley rat brain cortex homogenates incubated for 15 mins by liquid scintillation spectrometry
Toxicity in Swiss albino mouse assessed as induction of impairment of motor coordination by measuring reduction in time spent on rota-rod at 60 mg/kg, ip dosed 60 mins before test by rotarod test
Toxicity in Swiss albino mouse assessed as reduction in spontaneous locomotor activity at 60 mg/kg, ip dosed 60 mins before test and measured after 6 mins
Toxicity in Swiss albino mouse assessed as reduction in spontaneous locomotor activity at 60 mg/kg, ip dosed 60 mins before test and measured after 30 mins
Antidepressant-like activity in Swiss albino mouse assessed as reduction in immobility time at 7.5 mg/kg, ip dosed 1 hr before test by forced swimming test
Anxiolytic-like activity in Swiss albino mouse assessed as increase in time spent in open arms at 3.75 to 15 mg/kg measured for 5 mins test period by elevated plus maze test
In-vivo 5-HT1A receptor agonist activity in Swiss albino mouse assessed as induction of lower lip retraction by measuring lower lip retraction score at 30 mg/kg, ip dosed 15 mins before test (Rvb = 0.0 +/- 0.0 No_unit)
In-vivo 5-HT1A receptor antagonist activity in Swiss albino mouse assessed as reduction in 8-OH-DPAT-stimulated induction of lower lip retraction by measuring lower lip retraction score at 30 mg/kg, ip dosed 15 mins before test (Rvb = 2.875 +/- 0.08183 No_unit)