# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4197700 | B | Inhibition of gamma-secretase (unknown origin) | Homo sapiens | 8 | protein complex format | Scientific Literature | ||
2. | ALA4431691 | B | Modulation of gamma-secretase (unknown origin) assessed as inhibition of amyloid beta 42 production | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
3. | ALA4700758 | F | Inhibition of amyloid beta (1 to 42) secretion in human H4 cells overexpressing APP incubated for overnight by HTRF analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4700762 | F | Reduction in amyloid beta (1 to 42) secretion in brain in triple transgenic LaFerla mouse at 30 mg/kg, po measured after 3 hrs relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
5. | ALA4700764 | F | Reduction in amyloid beta (1 to 42) secretion in brain in Harlan Sprague-Dawley rat at 10 mg/kg, po measured after 3 hrs relative to control | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
6. | ALA4700768 | A | AUC (0 to 24 hrs) in Harlan Sprague-Dawley rat incubated for 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
7. | ALA4700775 | B | Inhibition of human ERG by patch clamp method | Homo sapiens | 2 | assay format | Scientific Literature | ||
8. | ALA4700778 | A | Inhibition of human UGT1A1 | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA4700779 | A | Inhibition of OATP1B1 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
10. | ALA4700781 | F | Inhibition of amyloid beta (1 to 42) secretion in human H4 cells overexpressing APP incubated for 24 hrs by MALDI-TOF mass spectrometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4700782 | F | Inhibition of amyloid beta (1 to 40) secretion in human H4 cells overexpressing APP incubated for 24 hrs by MALDI-TOF mass spectrometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4700783 | B | Modulation of gamma-secretase in human H4 cells overexpressing APP incubated assessed as increase in amyloid beta (1 to 37) secretion for 24 hrs by MALDI-TOF mass spectrometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4700784 | B | Modulation of gamma-secretase in human H4 cells overexpressing APP incubated assessed as increase in amyloid beta (1 to 38) secretion for 24 hrs by MALDI-TOF mass spectrometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4700785 | A | Suppression of total amyloid beta secretion in human H4 cells overexpressing APP up to 10 uM by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4700786 | P | Octanol/water partition coefficient, logD of the compound at pH 6.5 by shake flask method | 2 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA4700787 | A | Fraction unbound in human plasma measured after 24 hrs by LC-MS/MS analysis | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
17. | ALA4700788 | A | Plasma concentration in Harlan Sprague-Dawley rat at 10 mg/kg, po measured after 5 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4700789 | A | Ratio of drug level in brain to plasma in Harlan Sprague-Dawley rat at 10 mg/kg, po measured after 5 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4700790 | F | Antialzheimer activity in rat brain assessed as reduction in amyloid beta (1 to 42) AUC at 3 mg/kg measured after 24 hrs relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
20. | ALA4700791 | A | Plasma concentration in rat at 3 mg/kg measured after 24 hrs | Rattus norvegicus | 1 | organism-based format | Scientific Literature |