# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4184921 | B | Antagonist activity at CMV-fused VDR (unknown origin) expressed in HEK293T cells assessed as reduction in 24-hydroxylase promoter mediated transcriptional activity by luciferase reporter gene assay | Homo sapiens | 20 | ALA4184110 | cell-based format | Scientific Literature | |
2. | ALA4184922 | B | Transactivation of CMV-fused PPARdelta-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells by luciferase reporter gene assay | Homo sapiens | 20 | ALA4184110 | cell-based format | Scientific Literature | |
3. | ALA4184923 | B | Antagonist activity at VP16-fused VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of ligand-induced GAL4-fused SRC1 coactivator recruitment by two-hybrid luciferase reporter gene assay | Homo sapiens | 20 | ALA4184110 | cell-based format | Scientific Literature | |
4. | ALA4184925 | B | Agonist activity at VDR-LBD (unknown origin) assessed as recruitment of alexa fluor 647-labeled SRC2-3 after 30 mins by fluorescence polarization assay | Homo sapiens | 20 | ALA4184110 | single protein format | Scientific Literature | |
5. | ALA4184926 | B | Antagonist activity at VDR-LBD (unknown origin) assessed as inhibition of LG190178-induced recruitment of alexa fluor 647-labeled SRC2-3 after 30 mins by fluorescence polarization assay | Homo sapiens | 20 | ALA4184110 | single protein format | Scientific Literature | |
6. | ALA4184927 | A | Cytotoxicity against HEK293T cells assessed as decrease in cell viability at 100 uM after 18 hrs by Cell Titer-Glo based luminescence assay relative to control | Homo sapiens | 20 | ALA4184110 | cell-based format | Scientific Literature | |
7. | ALA4184928 | P | Aqueous solubility of the compound in DMSO at 500 uM by filter based assay | 20 | ALA4184110 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4184929 | A | Permeability of the compound after 18 hrs by PAMPA | 20 | ALA4184110 | assay format | Scientific Literature | ||
9. | ALA4184930 | B | Antagonist activity at CMV-fused PPARalpha-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of GW7647-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
10. | ALA4184931 | B | Antagonist activity at CMV-fused PPARgamma-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of rosiglitazone-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
11. | ALA4184932 | B | Antagonist activity at CMV-fused PPARdelta-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of GW0742-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
12. | ALA4184933 | B | Antagonist activity at CMV-fused RXRalpha-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of bexarotene-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
13. | ALA4184934 | B | Antagonist activity at CMV-fused TRalpha-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of T3-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
14. | ALA4184935 | B | Antagonist activity at CMV-fused TRbeta-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of T3-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
15. | ALA4184936 | B | Antagonist activity at CMV-fused ERalpha-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of estradiol-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
16. | ALA4184937 | B | Antagonist activity at CMV-fused ERbeta-LBD-GAL4-DBD (unknown origin) expressed in HEK293T cells assessed as inhibition of estradiol-induced receptor transactivation after 16 hrs by bright-Glo luciferase reporter gene assay | Homo sapiens | 4 | ALA4184110 | cell-based format | Scientific Literature | |
17. | ALA4184938 | A | Inhibition of Photuris pennsylvanica luciferase after 45 mins by CellTiter-Glo based luminescence assay | Photuris pennsylvanica | 2 | ALA4184110 | single protein format | Scientific Literature |