| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4202002 | A | Metabolic stability in CD1 mouse liver microsomes assessed as half life at 1 uM in presence of NADPH by LC-MS/MS analysis | Mus musculus | 5 | microsome format | Scientific Literature | ||
| 2. | ALA4202003 | P | Thermodynamic solubility of the compound by quantitative nitrogen detection assay | 10 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4202007 | B | Inhibition of human recombinant ALDH1A1 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry | Homo sapiens | 28 | single protein format | Scientific Literature | ||
| 4. | ALA4202008 | B | Inhibition of human recombinant ALDH1A2 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 5. | ALA4202010 | B | Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 6. | ALA4202012 | B | Inhibition of human recombinant ALDH2 assessed as enzyme activity by measuring NAD(P)H formation at 20 uM incubated for 2 mins by spectrophotometry | Homo sapiens | 31 | single protein format | Scientific Literature | ||
| 7. | ALA4202017 | B | Inhibition of ALDH1A3 in human PEO1 cells assessed as reduction in aldefluor positive cells at 1 uM incubated for 30 mins by aldefluor assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 8. | ALA4202018 | B | Inhibition of ALDH1A3 in human PEO1 cells assessed as reduction in aldefluor positive cells at 10 uM incubated for 30 mins by aldefluor assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 9. | ALA4202019 | B | Inhibition of ALDH1A3 in human OVCAR5 cells assessed as reduction in aldefluor positive cells at 1 uM incubated for 30 mins by aldefluor assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA4202020 | B | Inhibition of ALDH1A3 in human OVCAR5 cells assessed as reduction in aldefluor positive cells at 10 uM incubated for 30 mins by aldefluor assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4202023 | B | Inhibition of ALDH1A3 in human PEO1 cells assessed as reduction in CD133 protein expression incubated for 48 hrs by CD133/2-APC antibody based assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 12. | ALA4202024 | B | Inhibition of ALDH1A3 in human OVCAR5 cells assessed as reduction in CD133 protein expression incubated for 48 hrs by CD133/2-APC antibody based assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 13. | ALA4202029 | F | Potentiation of 6 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 1 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4202030 | F | Potentiation of 3 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 1 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA4202031 | F | Potentiation of 1.5 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 1 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA4202032 | F | Potentiation of 0.75 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 1 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA4202033 | F | Potentiation of 6 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 10 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA4202034 | F | Potentiation of 3 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 10 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA4202035 | F | Potentiation of 1.5 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 10 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4202036 | F | Potentiation of 0.75 uM cisplatin-induced cytotoxicity in human PEO1 cells assessed as combination index at 10 uM incubated for 72 hrs by cell-titer Glo assay based Chou-Talalay method | Homo sapiens | 4 | cell-based format | Scientific Literature |
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