# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4189777 | Binding | Displacement of fluorescein-labeled MLL4-43 from full length human menin expressed in Escherichia coli BL21 (DE3) cells after 3 hrs by fluorescence polarization assay | Homo sapiens | 29 | ALA4184328 | cell-based format | Scientific Literature | |
2. | ALA4189778 | Binding | Binding affinity to menin in mouse bone marrow cells harboring MLL-AF9 fusion protein assessed as inhibition of protein interaction with MLL by measuring cell growth inhibition after 7 days by MTT assay | Mus musculus | 29 | ALA4184328 | cell-based format | Scientific Literature | |
3. | ALA4189779 | ADME | Half life in CD-1 mouse liver microsomes at 1 uM after 3 to 60 mins by LC-MS/MS method | Mus musculus | 29 | ALA4184328 | microsome format | Scientific Literature | |
4. | ALA4189780 | Unassigned | Selectivity index, ratio of GI50 for mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 to GI50 for binding affinity to menin in mouse bone marrow cells harboring MLL-AF9 fusion protein assessed as inhibition of protein interaction with MLL by measuring cell growth inhibition | Mus musculus | 3 | ALA4184328 | cell-based format | Scientific Literature | |
5. | ALA4189783 | Functional | Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay | Homo sapiens | 2 | ALA4184328 | cell-based format | Scientific Literature | |
6. | ALA4189784 | Functional | Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay | Homo sapiens | 2 | ALA4184328 | cell-based format | Scientific Literature |