| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4182207 | B | Inhibition of HCV genotype 1b Con1 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay | Hepatitis C virus (isolate Con1) | 22 | cell-based format | Scientific Literature | ||
| 2. | ALA4182208 | B | Inhibition of HCV genotype 1a H77 NS3 protease infected in human HuH7 replicon cells assessed as reduction in viral replication after 4 days by luciferase reporter gene assay | Hepatitis C virus (isolate H77) | 21 | cell-based format | Scientific Literature | ||
| 3. | ALA4182212 | A | Half life in human liver microsomes in presence of NADPH | Homo sapiens | 12 | microsome format | Scientific Literature | ||
| 4. | ALA4182214 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, iv after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 5. | ALA4182215 | A | Half life in Sprague-Dawley rat at 5 mg/kg, iv after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA4182216 | A | AUC in Sprague-Dawley rat at 5 mg/kg, iv after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 7. | ALA4182217 | A | Drug concentration in Sprague-Dawley rat liver at 5 mg/kg, iv after 24 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA4182218 | A | Oral bioavailability in Sprague-Dawley rat at 15 mg/kg after 24 hrs | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA4182219 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in heart rate at 10 uM measured over 10 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 10. | ALA4182220 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in heart rate at 10 uM measured over 20 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 11. | ALA4182221 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in heart rate at 10 uM measured over 30 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 12. | ALA4182222 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in coronary flow at 10 uM measured over 10 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 13. | ALA4182223 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in coronary flow at 10 uM measured over 20 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 14. | ALA4182224 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in coronary flow at 10 uM measured over 30 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 15. | ALA4182225 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in sinus node recovery time at 10 uM measured over 10 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 16. | ALA4182226 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in sinus node recovery time at 10 uM measured over 20 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 17. | ALA4182227 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in QRS interval at 10 uM measured over 10 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 18. | ALA4182228 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in QRS interval at 10 uM measured over 20 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 19. | ALA4182229 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in QRS interval at 10 uM measured over 30 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature | ||
| 20. | ALA4182230 | T | Cardiotoxicity in Langendorff perfused rabbit heart assessed as change in PR interval at 10 uM measured over 10 mins by electrocardiography (Rvb = 0%) | Oryctolagus cuniculus | 2 | tissue-based format | Scientific Literature |
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