Agonist activity at human neuropeptide Y2 receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 120 mins by liquid scintillation counting method
Anorectic activity in C57BL/6J mouse assessed as inhibition of food intake at 1 mg/kg/day, sc for 3 days dosed as continuous administration by infusion using osmotic pump
Anorectic activity in C57BL/6J mouse assessed as inhibition of food intake at 0.3 mg/kg/day, sc for 3 days dosed as continuous administration by infusion using osmotic pump
Anorectic activity in C57BL/6J mouse assessed as inhibition of food intake at 0.1 mg/kg/day, sc for 3 days dosed as continuous administration by infusion using osmotic pump
Anorectic activity in C57BL/6J mouse assessed as inhibition of food intake at 0.03 mg/kg/day, sc for 3 days dosed as continuous administration by infusion using osmotic pump
Anorectic activity in C57BL/6J mouse assessed as inhibition of food intake at 0.3 mg/kg/day, sc dosed as bolus administration by infusion using osmotic pump and measured after 12 hrs
Anorectic activity in C57BL/6J mouse assessed as inhibition of food intake at 0.3 mg/kg/day, sc dosed as bolus administration by infusion using osmotic pump and measured after 24 hrs
Antiobesity activity in DIO C57BL/6J mouse assessed as reduction in body weight at 0.1 mg/kg, sc for 2 weeks dosed as continuous administration by infusion of osmotic pumps
Antiobesity activity in DIO C57BL/6J mouse assessed as reduction in body weight at 0.01 mg/kg, sc for 2 weeks dosed as continuous administration by infusion of osmotic pumps