# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4195521 | B | Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting method | Homo sapiens | 30 | ALA4190397 | cell-based format | Scientific Literature | |
2. | ALA4195522 | B | Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting method | Rattus norvegicus | 30 | ALA4190397 | single protein format | Scientific Literature | |
3. | ALA4195523 | A | Intrinsic clearance in human liver microsomes at 1 uM assessed per mg protein at 37 degC up to 60 mins in presence of NADPH by HPLC-MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
4. | ALA4195524 | A | Intrinsic clearance in rat liver microsomes at 1 uM assessed per mg protein at 37 degC up to 30 mins in presence of NADPH by HPLC-MS analysis | Rattus norvegicus | 30 | ALA4190397 | microsome format | Scientific Literature | |
5. | ALA4195525 | B | Inhibition of human ERG expressed in CHO cells at 10 nM to 10 uM at holding potential of -80 mV measured after 5 mins by QPatch automated patch clamp electrophysiology method | Homo sapiens | 30 | ALA4190397 | cell-based format | Scientific Literature | |
6. | ALA4195526 | A | Apparent permeability from apical to basolateral side in MDCK-MDR1 cells monolayer at 5 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 30 | ALA4190397 | cell-based format | Scientific Literature | |
7. | ALA4195527 | A | Apparent permeability from basolateral to apical side in MDCK-MDR1 cells monolayer at 5 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 30 | ALA4190397 | cell-based format | Scientific Literature | |
8. | ALA4195528 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK-MDR1 cells at 5 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 30 | ALA4190397 | cell-based format | Scientific Literature | |
9. | ALA4195529 | A | Plasma concentration in Sprague-Dawley rat at 10 mg/kg, po after 90 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4190397 | organism-based format | Scientific Literature | |
10. | ALA4195543 | B | Inhibition of recombinant human GlyT2 expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting method | Homo sapiens | 30 | ALA4190397 | cell-based format | Scientific Literature | |
11. | ALA4195544 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
12. | ALA4195545 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
13. | ALA4195546 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
14. | ALA4195547 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
15. | ALA4195548 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 7 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
16. | ALA4195549 | A | Inhibition of CYP3A5 in human liver microsomes using midazolam as substrate measured after 10 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4190397 | microsome format | Scientific Literature | |
17. | ALA4195550 | A | Drug uptake in Sprague-Dawley rat brain at 10 mg/kg, po after 90 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4190397 | organism-based format | Scientific Literature | |
18. | ALA4195551 | A | Drug uptake in Sprague-Dawley rat CSF at 10 mg/kg, po after 90 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4190397 | organism-based format | Scientific Literature | |
19. | ALA4195552 | A | Permeability of the compound at pH 7.4 at 100 uM after 60 mins by PAMPA-BBB assay | 13 | ALA4190397 | assay format | Scientific Literature | ||
20. | ALA4195553 | A | Unbound fraction in rat plasma at 1 uM by LC-MS/MS based equilibrium dialysis | Rattus norvegicus | 4 | ALA4190397 | cell-free format | Scientific Literature |