| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4200947 | B | Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10 mins followed by substrate addition measured over 5 mins by TR-FRET assay | Mus musculus | 14 | single protein format | Scientific Literature | ||
| 2. | ALA4200948 | B | Binding affinity to IDE E111Q mutant (unknown origin) using N-terminal FITC-labeled compound after 2 hrs in absence of light at 298 K by fluorescence polarization assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA4200949 | B | Selectivity ratio of IC50 for ECE-1 (unknown origin) to IC50 for mouse His-tagged IDE (42 to 1019 residues) | 1 | assay format | Scientific Literature | |||
| 4. | ALA4200950 | B | Selectivity ratio of IC50 for ACE (unknown origin) to IC50 for mouse His-tagged IDE (42 to 1019 residues) | 1 | assay format | Scientific Literature | |||
| 5. | ALA4200951 | B | Inhibition of IDE (unknown origin) assessed as potentiation of insulin-induced AKT phosphorylation in rat skeletal muscle cells at 100 uM preincubated for 10 mins followed insulin addition measured by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4200952 | B | Selectivity ratio of IC50 for NEP (unknown origin) to IC50 for mouse His-tagged IDE (42 to 1019 residues) | 1 | assay format | Scientific Literature | |||
| 7. | ALA4200953 | A | Drug uptake in human HeLa cells at 5 uM using FITC-labeled compound after 2 hrs at 310 K by DAPI-staining based confocal microscopy | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4200954 | A | Drug uptake in human HeLa cells at 5 uM using FITC-labeled compound after 2 hrs at 310 K by trypan blue-fluorescence based FACS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4200955 | A | Drug uptake in human HeLa cells at 5 uM using FITC-labeled compound after 2 hrs at 310 K by LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4200956 | A | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at <300 uM after 24 hrs at 310 K by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4200957 | A | Hemolytic activity against mouse RBC at 300 uM after 1 hr at 310 K | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4200958 | A | Metabolic stability in 25% mouse serum assessed as compound remaining at 250 uM up to 24 hrs by LC-MS analysis | Mus musculus | 2 | cell-free format | Scientific Literature | ||
| 13. | ALA4200959 | B | Inhibition of IDE (unknown origin) assessed as potentiation of insulin-induced AKT phosphorylation in rat skeletal muscle cells at 100 uM preincubated up to 12 hrs followed by insulin addition and measured after 10 mins by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4200960 | B | Inhibition of IDE (unknown origin)-mediated FITC-insulin degradation in rat skeletal muscle cells at 100 uM after 10 mins at 310 K by DAPI-staining based fluorescent inverted microscopic imaging analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4200961 | T | Toxicity in lean C57BL/6J mouse assessed as behavioral changes at 80 mg/kg, ip | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4200962 | T | Toxicity in lean C57BL/6J mouse assessed as body weight change at 80 mg/kg, ip after 3 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4200963 | F | Anti-diabetic activity in DIO C57BL/6J mouse model assessed as reduction in glucose levels at 80 mg/kg, ip administered 30 min prior to glucose stimulation measured up to 120 mins post glucose injection by GTT | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4200964 | A | Effect on glucose levels in lean C57BL/6J mouse at 80 mg/kg, ip administered 30 min prior to glucose stimulation measured up to 120 min post glucose injection by GTT | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4200965 | F | Hypoglycemic activity in lean C57BL/6J mouse at 80 mg/kg, ip administered 30 min prior to insulin injection measured up to 75 mins post insulin injection by ITT | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4200966 | A | Drug uptake in brain parenchyma of DIO C57BL/6J mouse at 80 mg/kg, iv using FITC-labeled compound by two-photon microscopic analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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