# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4187427 | B | Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B catalytic fragment (Met1 to Leu543 residues) assessed as reduction in glucosyltransferase domain UDP-glucose hydrolysis activity using UDP-glucose and ADP Alexa633 tracer incubated fore 3 hrs by fluorescence polarization assay | Clostridioides difficile | 45 | single protein format | Scientific Literature | ||
2. | ALA4187432 | F | Effect on growth of Clostridium difficile at 0.5 to 100 uM incubated for 24 hrs under anaerobic conditions by spectrophotometry | Clostridioides difficile | 45 | organism-based format | Scientific Literature | ||
3. | ALA4187433 | A | Effect on growth of Lactobacillus reuteri at 0.5 to 100 uM incubated for 24 hrs under anaerobic conditions by spectrophotometry | Limosilactobacillus reuteri | 45 | organism-based format | Scientific Literature | ||
4. | ALA4187434 | A | Effect on growth of Bifidobacterium longum at 0.5 to 100 uM incubated for 24 hrs under anaerobic conditions by spectrophotometry | Bifidobacterium longum | 45 | organism-based format | Scientific Literature | ||
5. | ALA4187435 | A | Effect on growth of Bacteroides fragilis at 0.5 to 100 uM incubated for 48 hrs under anaerobic conditions by spectrophotometry | Bacteroides fragilis | 45 | organism-based format | Scientific Literature | ||
6. | ALA4328864 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 15 mins | Homo sapiens | 33 | microsome format | Scientific Literature | ||
7. | ALA4328865 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining after 15 mins | Mus musculus | 33 | microsome format | Scientific Literature | ||
8. | ALA4328867 | B | Inhibition of Clostridium difficile toxin B transfected in CHO cells assessed as reduction in caspase 3/7 activation pre-incubated for 1 hr before TcdB addition by luminescence based assay | Clostridioides difficile | 35 | cell-based format | Scientific Literature | ||
9. | ALA4328868 | B | Inhibition of Clostridium difficile toxin A transfected in CHO cells assessed as reduction in caspase 3/7 activation pre-incubated for 1 hr before TcdA addition by luminescence based assay | Clostridioides difficile | 33 | cell-based format | Scientific Literature | ||
10. | ALA4328869 | B | Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B glucosyltransferase domain assessed as reduction in UDP-glucose hydrolysis activity using UDP-glucose substrate and ADP Alexa633 tracer incubated for 3 hrs by fluorescence polarization assay | 33 | single protein format | Scientific Literature |