| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4178567 | B | Binding affinity to human PAD2 expressed in HEK293T cells assessed as protein occupancy preincubated for 15 mins followed by ionomycin addition measured after 1 hr in presence of CaCl2 by RIBFA probe based SDS-PAGE analysis | Homo sapiens | 6 | ALA4177546 | cell-based format | Scientific Literature | |
| 2. | ALA4178568 | B | Binding affinity to human PAD2 expressed in HEK293T cells assessed as protein occupancy at 25 uM preincubated for 15 mins followed by ionomycin addition measured after 1 hr in presence of CaCl2 by RIBFA probe based SDS-PAGE analysis relative to control | Homo sapiens | 8 | ALA4177546 | cell-based format | Scientific Literature | |
| 3. | ALA4178569 | B | Binding affinity to human PAD2 expressed in HEK293T cells assessed as decrease in histone H3 citrulination incubated for 3 hrs in presence of ionomycin/CaCl2 by SDS-PAGE analysis | Homo sapiens | 5 | ALA4177546 | cell-based format | Scientific Literature | |
| 4. | ALA4178570 | A | Safety index, ratio of compound EC50 to BB-Cl-amide EC50 for cytotoxicity against HEK293T cells | Homo sapiens | 4 | ALA4177546 | cell-based format | Scientific Literature | |
| 5. | ALA4178574 | B | Selectivity ratio of Kinact/Ki for recombinant His6-tagged PAD1 (unknown origin) to Kinact/Ki for recombinant full length N-terminal GST-tagged human PAD4 expressed in Escherichia coli Rosetta cells | Homo sapiens | 36 | ALA4177546 | cell-based format | Scientific Literature | |
| 6. | ALA4178575 | B | Selectivity ratio of Kinact/Ki for recombinant human PAD2 expressed in Escherichia coli BL21(DE3)pLysS cells to Kinact/Ki for recombinant full length N-terminal GST-tagged human PAD4 expressed in Escherichia coli Rosetta cells | Homo sapiens | 40 | ALA4177546 | cell-based format | Scientific Literature | |
| 7. | ALA4178576 | B | Selectivity ratio of Kinact/Ki for recombinant His6-tagged PAD3 (unknown origin) to Kinact/Ki for recombinant full length N-terminal GST-tagged human PAD4 expressed in Escherichia coli Rosetta cells | Homo sapiens | 36 | ALA4177546 | cell-based format | Scientific Literature | |
| 8. | ALA4178578 | B | Selectivity ratio of Kinact/Ki for recombinant human PAD2 expressed in Escherichia coli BL21(DE3)pLysS to Kinact/Ki for recombinant His6-tagged PAD3 (unknown origin) | Homo sapiens | 23 | ALA4177546 | assay format | Scientific Literature |
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