# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4202266 | Binding | Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs by fluorescence polarization assay | Homo sapiens | 28 | ALA4196231 | assay format | Scientific Literature | |
2. | ALA4202267 | Binding | Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs by fluorescence polarization assay | Homo sapiens | 28 | ALA4196231 | assay format | Scientific Literature | |
3. | ALA4202270 | Binding | Ratio of Ki for displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) to Ki for displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 27 | ALA4196231 | assay format | Scientific Literature | |
4. | ALA5168032 | Binding | Binding affinity to MBP-tagged human recombinant AF9 (487 to 568 residues) incubated for 40 mins by measuring fluorescence polarization by microplate reader method | Homo sapiens | 14 | ALA5154930 | single protein format | Scientific Literature | |
5. | ALA5168033 | Binding | Binding affinity to MBP-tagged human recombinant ENL (489 to 559 residues) incubated for 40 mins by measuring fluorescence polarization by microplate reader method | Homo sapiens | 14 | ALA5154930 | single protein format | Scientific Literature | |
6. | ALA5168034 | Functional | Anticancer activity against human MOLM-13 cells harbouring MLL-AF9 assessed as inhibition of cell growth treated for 8 days measured by CCK-8 kit method | Homo sapiens | 12 | ALA5154930 | cell-based format | Scientific Literature | |
7. | ALA5168035 | Functional | Anticancer activity against human KOPN-8 cells harbouring MLL-ENL assessed as inhibition of cell growth treated for 8 days measured by CCK-8 kit method | Homo sapiens | 12 | ALA5154930 | cell-based format | Scientific Literature | |
8. | ALA5168036 | Functional | Anticancer activity against human RS4-11 cells assessed as inhibition of cell growth treated for 8 days measured by CCK-8 kit method | Homo sapiens | 12 | ALA5154930 | cell-based format | Scientific Literature | |
9. | ALA5168037 | Functional | Anticancer activity against human MV4-11 cells assessed as inhibition of cell growth treated for 8 days measured by CCK-8 kit method | Homo sapiens | 12 | ALA5154930 | cell-based format | Scientific Literature | |
10. | ALA5168038 | Functional | Anticancer activity against human K562 cells assessed as inhibition of cell growth treated for 8 days measured by CCK-8 kit method | Homo sapiens | 12 | ALA5154930 | cell-based format | Scientific Literature | |
11. | ALA5168046 | ADME | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 5 | ALA5154930 | cell-based format | Scientific Literature | |
12. | ALA5168047 | ADME | Stability in human plasma assessed as compound remaining measured upto 1440 mins by HPLC analysis | Homo sapiens | 5 | ALA5154930 | cell-free format | Scientific Literature |