| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4189646 | B | Inhibition of recombinant human BTK using Poly(Glu, Tyr) 4:1 as substrate after 1 hr by ELISA | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 2. | ALA4189652 | A | Clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 3. | ALA4189653 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA4189654 | A | Half life in rat at 1 mg/kg, iv | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA4189655 | A | Cmax in rat at 3 mg/kg, po | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA4189656 | A | Tmax in rat at 3 mg/kg, po | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4189657 | A | AUC (0 to infinity) in rat at 3 mg/kg, po | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 8. | ALA4189658 | A | Oral bioavailability in rat at 3 mg/kg | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA4189659 | A | Drug metabolism in mouse liver microsomes assessed as (S)-N-(4-amino-5-(4-(4-hydroxyphenoxy)phenyl)-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)acrylamide formation after 3 hrs | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 10. | ALA4189660 | A | Drug metabolism in rat liver microsomes assessed as (S)-N-(4-amino-5-(4-(4-hydroxyphenoxy)phenyl)-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)acrylamide formation after 3 hrs | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 11. | ALA4189661 | A | Drug metabolism in human liver microsomes assessed as (S)-N-(4-amino-5-(4-(4-hydroxyphenoxy)phenyl)-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)acrylamide formation after 3 hrs | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4189662 | A | Drug metabolism in mouse liver microsomes assessed as (S,E)-N-(4-amino-6-methylene-5-(4-phenoxyphenyl)-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)-3-hydroxyacrylamide formation after 3 hrs | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 13. | ALA4189663 | A | Drug metabolism in rat liver microsomes assessed as (S,E)-N-(4-amino-6-methylene-5-(4-phenoxyphenyl)-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)-3-hydroxyacrylamide formation after 3 hrs | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 14. | ALA4189664 | A | Drug metabolism in human liver microsomes assessed as (S,E)-N-(4-amino-6-methylene-5-(4-phenoxyphenyl)-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)-3-hydroxyacrylamide formation after 3 hrs | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 15. | ALA4189665 | A | Drug metabolism in mouse liver microsomes assessed as N-((S)-4-amino-6-methylene-5-(4-phenoxyphenyl)-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)-2,3-dihydroxypropanamide formation after 3 hrs | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 16. | ALA4189666 | A | Drug metabolism in rat liver microsomes assessed as N-((S)-4-amino-6-methylene-5-(4-phenoxyphenyl)-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)-2,3-dihydroxypropanamide formation after 3 hrs | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 17. | ALA4189667 | A | Drug metabolism in human liver microsomes assessed as N-((S)-4-amino-6-methylene-5-(4-phenoxyphenyl)-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)-2,3-dihydroxypropanamide formation after 3 hrs | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 18. | ALA4189669 | A | Drug metabolism in rat liver microsomes assessed as (S)-N-(4-amino-5-(4-hydroxyphenyl)-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)acrylamide formation after 3 hrs | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
| 19. | ALA4189670 | A | Drug metabolism in human liver microsomes assessed as (S)-N-(4-amino-5-(4-hydroxyphenyl)-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-7-yl)acrylamide formation after 3 hrs | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 20. | ALA4189671 | A | Drug metabolism in mouse liver microsomes assessed as (S)-4-(4-(4,7-diamino-6-methylene-7,8-dihydro-6H-pyrimido[5,4-b]pyrrolizin-5-yl)phenoxy)phenol formation after 3 hrs | Mus musculus | 2 | microsome format | Scientific Literature |
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