# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4200610 | B | Inhibition of human kidney uPA using Z-Gly-Gly-Arg-AMC as substrate measured over 15 mins by fluorescence assay | Homo sapiens | 30 | ALA4196166 | single protein format | Scientific Literature | |
2. | ALA4200621 | B | Inhibition of trypsin (unknown origin) at 10 nM to 33.3 uM after 30 mins by gel-based ABPP assay | Homo sapiens | 3 | ALA4196166 | protein format | Scientific Literature | |
3. | ALA4200626 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay | Homo sapiens | 5 | ALA4196166 | cell-based format | Scientific Literature | |
4. | ALA4200627 | F | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay | Homo sapiens | 5 | ALA4196166 | cell-based format | Scientific Literature | |
5. | ALA4200628 | A | Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay | Homo sapiens | 5 | ALA4196166 | cell-based format | Scientific Literature | |
6. | ALA4200629 | F | Cytotoxicity against human HT1080 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay | Homo sapiens | 5 | ALA4196166 | cell-based format | Scientific Literature | |
7. | ALA4200630 | P | Lipophilicity, log D of the compound at pH 7.4 | 4 | ALA4196166 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4200634 | A | Inhibition of S-3969-stimulated recombinant human ENaC alpha subunit expressed in HEK293 cells at 10 uM preincubated for 5 mins followed by S-3969 stimulation by FLIPR assay | Homo sapiens | 6 | ALA4196166 | cell-based format | Scientific Literature | |
9. | ALA4200635 | A | Inhibition of S-3969-stimulated recombinant human ENaC beta subunit expressed in HEK293 cells at 10 uM preincubated for 5 mins followed by S-3969 stimulation by FLIPR assay | Homo sapiens | 6 | ALA4196166 | cell-based format | Scientific Literature | |
10. | ALA4200636 | A | Inhibition of S-3969-stimulated recombinant human ENaC gamma subunit expressed in HEK293 cells at 10 uM preincubated for 5 mins followed by S-3969 stimulation by FLIPR assay | Homo sapiens | 6 | ALA4196166 | cell-based format | Scientific Literature | |
11. | ALA4200648 | B | Inhibition of human kidney uPA after 30 mins by gel-based ABPP assay | Homo sapiens | 1 | ALA4196166 | single protein format | Scientific Literature | |
12. | ALA4739457 | P | Distribution coefficient, log D of the compound at pH 7.4 by HPLC analysis | 14 | ALA4732263 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4739458 | P | Kinetic solubility of compound in HCL at pH 2 by nephelometric analysis | 14 | ALA4732263 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4739459 | P | Kinetic solubility of compound in PBS at pH 6.5 by nephelometric analysis | 14 | ALA4732263 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4739460 | A | Half life in human liver microsomes at 1 uM up to 60 mins in presence of NADPH | Homo sapiens | 14 | ALA4732263 | microsome format | Scientific Literature | |
16. | ALA4739461 | A | Intrinsic clearance in human liver microsomes at 1 uM up to 60 mins in presence of NADPH | Homo sapiens | 14 | ALA4732263 | microsome format | Scientific Literature | |
17. | ALA4739462 | A | Unbound intrinsic clearance in human liver microsomes at 1 uM up to 60 mins in presence of NADPH | Homo sapiens | 14 | ALA4732263 | microsome format | Scientific Literature | |
18. | ALA4739463 | A | Half life in mouse liver microsomes at 1 uM up to 60 mins in presence of NADPH | Mus musculus | 14 | ALA4732263 | microsome format | Scientific Literature | |
19. | ALA4739464 | A | Intrinsic clearance in mouse liver microsomes at 1 uM up to 60 mins in presence of NADPH | Mus musculus | 14 | ALA4732263 | microsome format | Scientific Literature | |
20. | ALA4739465 | A | Unbound intrinsic clearance in mouse liver microsomes at 1 uM up to 60 mins in presence of NADPH | Mus musculus | 14 | ALA4732263 | microsome format | Scientific Literature |