# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4199684 | B | Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay | Homo sapiens | 19 | ALA4196117 | cell-based format | Scientific Literature | |
2. | ALA4199685 | B | Inhibition of recombinant human HL expressed in African green monkey COS7 cells using HDL as substrate pretreated for 10 mins followed by substrate addition and measured after 30 mins by LC/MS/MS analysis | Homo sapiens | 2 | ALA4196117 | cell-based format | Scientific Literature | |
3. | ALA4199686 | B | Inhibition of recombinant human LPL expressed in African green monkey COS7 cells using DGGR/DMPG vesicles as substrate pretreated for 10 mins followed by substrate addition and measured for 5 mins | Homo sapiens | 2 | ALA4196117 | cell-based format | Scientific Literature | |
4. | ALA4199687 | B | Reversible inhibition of endothelial lipase in human HT1080 cells at 2 uM using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by compound washout prior to substrate addition and measured every 20 secs for 10 mins by fluorescence assay | Homo sapiens | 1 | ALA4196117 | cell-based format | Scientific Literature | |
5. | ALA4199688 | P | Dissociation constant, pKa of the compound | 2 | ALA4196117 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4199689 | A | Cmax in CD1 mouse at 1 mg/kg, iv administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature | |
7. | ALA4199690 | A | Total AUC in CD1 mouse at 1 mg/kg, iv administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature | |
8. | ALA4199691 | A | Clearance in CD1 mouse at 1 mg/kg, iv administered as bolus dose | Mus musculus | 2 | ALA4196117 | organism-based format | Scientific Literature | |
9. | ALA4199692 | A | Half life in CD1 mouse at 1 mg/kg, iv administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature | |
10. | ALA4199693 | A | Cmax in CD1 mouse at 1 mg/kg, po administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature | |
11. | ALA4199694 | A | Total AUC in CD1 mouse at 1 mg/kg, po administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature | |
12. | ALA4199695 | A | Half life in CD1 mouse at 1 mg/kg, po administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature | |
13. | ALA4199696 | A | Oral bioavailability in CD1 mouse at 1 mg/kg administered as bolus dose | Mus musculus | 3 | ALA4196117 | organism-based format | Scientific Literature |