| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4201826 | B | Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 at 40 uM pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 5 | ALA4196210 | assay format | Scientific Literature | |
| 2. | ALA4201827 | B | Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 43 | ALA4196210 | assay format | Scientific Literature | |
| 3. | ALA4201828 | B | Inhibition of trypsin (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 41 | ALA4196210 | protein format | Scientific Literature | |
| 4. | ALA4201829 | B | Inhibition of thrombin (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 6 | ALA4196210 | single protein format | Scientific Literature | |
| 5. | ALA4201830 | B | Inhibition of factor 10a (unknown origin) pre-incubated for 30 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 6 | ALA4196210 | single protein format | Scientific Literature | |
| 6. | ALA4201831 | B | Binding affinity to His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 assessed as covalent adduct formation by measuring mass shift at 100 to 200 uM incubated for 1 hr by ESI-MS analysis | Homo sapiens | 2 | ALA4196210 | assay format | Scientific Literature | |
| 7. | ALA4201832 | B | Binding affinity to His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 assessed as covalent adduct formation at Ser195 at 100 to 200 uM incubated for 1 hr by ESI-MS analysis | Homo sapiens | 2 | ALA4196210 | assay format | Scientific Literature | |
| 8. | ALA4201833 | B | Binding affinity to His-6-tagged human KLK6 R74G/R76Q/N132Q/S195A mutant expressed in Escherichia coli DH10 assessed as covalent adduct formation at 100 to 200 uM incubated for 1 hr by ESI-MS analysis | Homo sapiens | 2 | ALA4196210 | assay format | Scientific Literature | |
| 9. | ALA4201834 | B | Binding affinity to His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 assessed as covalent adduct formation at 100 to 200 uM incubated for 24 hrs by ESI-MS analysis | Homo sapiens | 1 | ALA4196210 | assay format | Scientific Literature | |
| 10. | ALA4201835 | B | Binding affinity to His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 assessed as covalent adduct formation at 100 to 200 uM incubated for 48 hrs by ESI-MS analysis | Homo sapiens | 1 | ALA4196210 | assay format | Scientific Literature | |
| 11. | ALA4201838 | B | Time dependent inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated up to 40 mins before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 1 | ALA4196210 | assay format | Scientific Literature | |
| 12. | ALA4201839 | B | Inhibition of His-6-tagged human KLK6 R74G/R76Q/N132Q mutant expressed in Escherichia coli DH10 pre-incubated for 4 hrs before N-Boc-FSR-AMC substrate addition and measured after 30 mins | Homo sapiens | 1 | ALA4196210 | assay format | Scientific Literature | |
| 13. | ALA4201853 | P | Stability in DMEM supplemented with 10% (v/v) fetal bovine serum at 10 uM at 37 degC assessed as half life by HPLC-MS method | 7 | ALA4196210 | small-molecule physicochemical format | Scientific Literature |
The page will load shortly, Thanks for your patience!