# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4189991 | Binding | Inhibition of human ALDH1A1 using NAD+/propionaldehyde as substrate/cofactor preincubated for 15 mins followed by substrate/cofactor addition measured for 30 mins by fluorescence assay | Homo sapiens | 107 | ALA4184337 | single protein format | Scientific Literature | |
2. | ALA4189992 | Binding | Inhibition of ALDH1A1 in human MIAPaCa2 cells after 30 mins by aldefluor assay | Homo sapiens | 107 | ALA4184337 | cell-based format | Scientific Literature | |
3. | ALA4189997 | Binding | Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature after 1 hr by CETSA | Homo sapiens | 5 | ALA4184337 | cell-based format | Scientific Literature | |
4. | ALA4189998 | Binding | Stabilization of ALDH1A1 in human OV90 cells assessed as increase in melting temperature at 70 degC after 1 hr by CETSA | Homo sapiens | 8 | ALA4184337 | cell-based format | Scientific Literature | |
5. | ALA4190000 | Functional | Cytotoxicity against 3D culture of human OV90 cells assessed as decrease in cell viability after 6 days by CellTiter-Glo assay | Homo sapiens | 8 | ALA4184337 | cell-based format | Scientific Literature | |
6. | ALA4190002 | Binding | Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assay | Homo sapiens | 6 | ALA4184337 | cell-based format | Scientific Literature | |
7. | ALA4190055 | Binding | Inhibition of full length recombinant human ALDH1A1 expressed in Escherichia coli BL21 cells using acetyladehyde as substrate preincubated for 5 mins followed by substrate addition measured every 40 secs for 4 mins | Homo sapiens | 1 | ALA4184337 | cell-based format | Scientific Literature | |
8. | ALA5150270 | Binding | Inhibition of ALDH1A1 (unknown origin) | Homo sapiens | 6 | ALA5149964 | single protein format | Scientific Literature |