# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4185000 | Binding | Inhibition of 20s constitutive proteasome beta1 caspase-like activity in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate at 50 uM after 10 mins by fluorescence assay relative to control | Homo sapiens | 10 | ALA4184119 | cell-based format | Scientific Literature | |
2. | ALA4185002 | Binding | Inhibition of 20s constitutive proteasome beta2 trypsin-like activity in human erythrocytes using Boc-Leu-Arg-Arg-AMC as substrate at 50 uM after 10 mins by fluorescence assay relative to control | Homo sapiens | 10 | ALA4184119 | cell-based format | Scientific Literature | |
3. | ALA4185004 | Binding | Inhibition of 20s immunoproteasome beta2 trypsin-like activity in human spleen using Boc-Leu-Arg-Arg-AMC as substrate at 50 uM after 10 mins by fluorescence assay relative to control | Homo sapiens | 8 | ALA4184119 | single protein format | Scientific Literature | |
4. | ALA4185006 | Binding | Inhibition of 20s constitutive proteasome beta5 chymotrypsin-like activity in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate at 50 uM after 10 mins by fluorescence assay relative to control | Homo sapiens | 8 | ALA4184119 | cell-based format | Scientific Literature | |
5. | ALA4185009 | Binding | Inhibition of 20s immunoproteasome beta5 chymotrypsin-like activity in human spleen using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 10 mins by fluorescence assay | Homo sapiens | 6 | ALA4184119 | single protein format | Scientific Literature | |
6. | ALA4185011 | Binding | Inhibition of 20s immunoproteasome beta1 caspase-like activity in human spleen using Ac-Pro-Ala-Leu-AMC as substrate after 10 mins by fluorescence assay | Homo sapiens | 3 | ALA4184119 | single protein format | Scientific Literature | |
7. | ALA4185012 | Binding | Selectivity ratio of inhibitory concentration for 20s constitutive proteasome beta5 chymotrypsin-like activity in human erythrocytes to Ki for 20s immunoproteasome beta5 chymotrypsin-like activity in human spleen | Homo sapiens | 2 | ALA4184119 | cell-based format | Scientific Literature | |
8. | ALA4185013 | Functional | Growth inhibition of human MM1R cells after 24 hrs by MTT assay | Homo sapiens | 6 | ALA4184119 | assay format | Scientific Literature |