| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4182988 | B | Displacement of BODIPY-labeled ligand from human His-tagged RORgammat after 20 mins by TR-FRET assay | Homo sapiens | 16 | ALA4177746 | single protein format | Scientific Literature | |
| 2. | ALA4182989 | B | Inverse agonist activity at RORgammat in human Jurkat cells assessed as inhibition of transcriptional activity after overnight incubation by human IL-17 ROR response element driven-bright-glo luciferase reporter gene assay | Homo sapiens | 16 | ALA4177746 | cell-based format | Scientific Literature | |
| 3. | ALA4182990 | A | AUC (0 to 8 hrs) in mouse at 1 mg/kg, po administered via cassette dose by LC-MS/MS analysis | Mus musculus | 16 | ALA4177746 | organism-based format | Scientific Literature | |
| 4. | ALA4182991 | A | Oral bioavailability in mouse at 1 mg/kg administered via cassette dose by LC-MS/MS analysis | Mus musculus | 16 | ALA4177746 | organism-based format | Scientific Literature | |
| 5. | ALA4182994 | F | In vivo inverse agonist activity at RORgammat in Balb/c mouse assessed as inhibition of IL-23-induced IL-17A cytokine expression at 100 mg/kg, po administered 30 mins before and 8 hrs after IL-23 injection in ears intradermally measured after 24 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4177746 | organism-based format | Scientific Literature | |
| 6. | ALA4186866 | B | Selectivity ratio of IC50 for RORbeta in human Jurkat cells to IC50 for RORgammat in human Jurkat cells | Homo sapiens | 2 | ALA4184189 | cell-based format | Scientific Literature | |
| 7. | ALA4186867 | B | Selectivity ratio of IC50 for RORalpha in human Jurkat cells to IC50 for RORgammat in human Jurkat cells | Homo sapiens | 2 | ALA4184189 | cell-based format | Scientific Literature | |
| 8. | ALA4186868 | A | AUC (0 to 8 hrs) in mouse at 1 mg/kg, po administered as cassette dose | Mus musculus | 5 | ALA4184189 | organism-based format | Scientific Literature | |
| 9. | ALA4186869 | B | Displacement of BODIPY-cholesterol from human His-tagged RORgammat after 20 mins by TR-FRET assay | Homo sapiens | 22 | ALA4184189 | single protein format | Scientific Literature | |
| 10. | ALA4186870 | B | Inverse agonist activity at RORgammat in human Jurkat cells assessed as inhibition of transcriptional activity after overnight incubation by human IL-17 ROR response element driven-bright-glo luciferase reporter gene assay | Homo sapiens | 22 | ALA4184189 | cell-based format | Scientific Literature | |
| 11. | ALA4186871 | F | In vivo inverse agonist activity at RORgammat in Balb/c mouse assessed as inhibition of IL-23-induced IL-17a gene expression at 100 mg/kg, po administered 30 mins before and 8 hrs after IL-23 injection in ears intradermally measured after 24 hrs by qRT-PCR analysis relative to control | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 12. | ALA4186872 | A | Cmax in mouse plasma at 100 mg/kg, po | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 13. | ALA4186873 | A | Tmax in mouse plasma at 100 mg/kg, po | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 14. | ALA4186874 | A | AUC (0 to 24 hrs) in mouse plasma at 100 mg/kg, po | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 15. | ALA4186875 | A | Drug uptake in Balb/c mouse plasma at 10 to 100 mg/kg, po | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 16. | ALA4186876 | A | Drug uptake in po dosed Balb/c mouse ear | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 17. | ALA4186877 | A | Drug uptake in po dosed Balb/c mouse ear after 8 hrs | Mus musculus | 1 | ALA4184189 | organism-based format | Scientific Literature | |
| 18. | ALA4186878 | B | Selectivity ratio of IC50 for androgen receptor (unknown origin) to IC50 for RORgammat in human Jurkat cells | Homo sapiens | 1 | ALA4184189 | cell-based format | Scientific Literature | |
| 19. | ALA4186879 | B | Selectivity ratio of IC50 for recombinant human ERbeta expressed in baculovirus infected Sf9 insect cells to IC50 for RORgammat in human Jurkat cells | Homo sapiens | 1 | ALA4184189 | cell-based format | Scientific Literature | |
| 20. | ALA4186880 | B | Selectivity ratio of IC50 for human GST-tagged ERalpha (282 to 595 residues) expressed in baculovirus infected insect cells to IC50 for RORgammat in human Jurkat cells | Homo sapiens | 1 | ALA4184189 | cell-based format | Scientific Literature |
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