| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4195474 | B | Antagonist activity at human TLR7 expressed in HEK293 cells assessed as inhibition of R848-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay | Homo sapiens | 71 | ALA4190396 | cell-based format | Scientific Literature | |
| 2. | ALA4195475 | B | Inhibition of human TLR7 expressed in HEK293 cells assessed as decrease in R848-induced NF-kappaB activation-mediated SEAP production at 5 uM after 24 hrs by Quanti-blue-based assay relative to control | Homo sapiens | 15 | ALA4190396 | cell-based format | Scientific Literature | |
| 3. | ALA4195476 | B | Antagonist activity at human TLR1/2 expressed in HEK293 cells assessed as decrease in Pam3CSK4-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 4. | ALA4195477 | B | Antagonist activity at human TLR5 expressed in HEK293 cells assessed as decrease in flagellin-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 5. | ALA4195478 | B | Antagonist activity at human TLR4 expressed in HEK293 cells assessed as decrease in LPS-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 6. | ALA4195479 | F | Growth inhibition of human HeLa cells by WST1 assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 7. | ALA4195480 | F | Induction of apoptosis in human HeLa cells after 24 hrs by Annexin-V FITC/propidium iodide staining based flow cytometry | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 8. | ALA4195481 | F | Cell cycle arrest in human HeLa cells assessed as accumulation at G0/G1 phase at 5 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 49.4%) | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 9. | ALA4195482 | B | Antagonist activity at human TLR2/6 expressed in HEK293 cells assessed as decrease in Pam2CSK4-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 10. | ALA4195483 | B | Antagonist activity at human TLR3 expressed in HEK293 cells assessed as decrease in poly I:C-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 11. | ALA4195484 | B | Antagonist activity at human TLR8 expressed in HEK293 cells assessed as decrease in R848-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 12. | ALA4195485 | B | Antagonist activity at human TLR9 expressed in HEK293 cells assessed as decrease in CpG-ODN2006-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 13. | ALA4195486 | B | Antagonist activity at human TLR7 expressed in HEK293 cells assessed as decrease in R848-induced NF-kappaB activation-mediated SEAP production at 10'-9 to 10'-5 M after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 14. | ALA4195487 | A | Cytotoxicity against HEK293 cells expressing human TLR7 assessed as reduction in cell viability up to 20 uM after 24 hrs by WST-1 assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 15. | ALA4195488 | B | Inhibition of TNFR in TLR null HEK-blue cells assessed as decrease in TNFalpha-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 16. | ALA4195489 | B | Inhibition of IL1R in TLR null HEK-blue cells assessed as decrease in IL-1beta-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 17. | ALA4195490 | B | Inhibition of PKC in TLR null HEK-blue cells assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 18. | ALA4195491 | B | Inhibition of PKC in HEK-blue cells expressing human TLR7 assessed as inhibition of PMA-induced NF-kappaB activation-mediated SEAP production after 24 hrs by Quanti-blue-based assay | Homo sapiens | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 19. | ALA4195492 | B | Inhibition of IFN-gamma-induced NFkappaB activation in mouse RAW264.7 cells assessed as reduction in nitric oxide production after 18 hrs by DAN assay | Mus musculus | 1 | ALA4190396 | cell-based format | Scientific Literature | |
| 20. | ALA4195493 | B | Inhibition of LPS-induced NFkappaB activation in mouse RAW264.7 cells assessed as reduction in nitric oxide production after 18 hrs by DAN assay | Mus musculus | 1 | ALA4190396 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!