# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4179116 | A | Cytotoxicity in human Friedreich's ataxia lymphocytes assessed as reduction in cell viability at 2.5 uM incubated for 24 hrs by Live/Dead cell viability assay | Homo sapiens | 5 | ALA4177577 | cell-based format | Scientific Literature | |
2. | ALA4179117 | A | Cytotoxicity in human Friedreich's ataxia lymphocytes assessed as reduction in cell viability at 2.5 uM incubated for 48 hrs by Live/Dead cell viability assay | Homo sapiens | 6 | ALA4177577 | cell-based format | Scientific Literature | |
3. | ALA4179118 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye monomer level at 1 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 10.1%) | Homo sapiens | 8 | ALA4177577 | cell-based format | Scientific Literature | |
4. | ALA4179119 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye aggregates level at 1 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 69.8%) | Homo sapiens | 8 | ALA4177577 | cell-based format | Scientific Literature | |
5. | ALA4179120 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye monomer level at 5 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 10.1%) | Homo sapiens | 7 | ALA4177577 | cell-based format | Scientific Literature | |
6. | ALA4179121 | F | Induction of mitochondrial membrane potential preservation in human Friedreich's ataxia lymphocytes assessed as JC1 dye aggregates level at 5 uM pre-incubated for 24 hrs by JC1 staining based assay (Rvb = 69.8%) | Homo sapiens | 7 | ALA4177577 | cell-based format | Scientific Literature | |
7. | ALA4179122 | F | Cytoprotection against buthionine sulfoximine-induced cytotoxicity in human Friedreich's ataxia lymphocytes assessed as increase in cell viability at 25 to 1000 nM pre-incubated before buthionine sulfoximine challenge for 48 hrs by Live/Dead cell viability assay | Homo sapiens | 5 | ALA4177577 | cell-based format | Scientific Literature | |
8. | ALA4179123 | F | Inhibition of ROS generation in human Friedreich's ataxia lymphocytes at 250 and 2500 nM incubated for 16 hrs by DCFH-DA staining based FACS method | Homo sapiens | 6 | ALA4177577 | cell-based format | Scientific Literature | |
9. | ALA4179124 | F | Cytoprotection against rotenone-induced cytotoxicity in human Friedreich's ataxia lymphocytes assessed as increase in cell viability at 0.25 and 2.5 uM pre-incubated for 12 hrs in glucose-free media followed by rotenone challenge for 24 hrs by Live/Dead cell viability assay | Homo sapiens | 7 | ALA4177577 | cell-based format | Scientific Literature | |
10. | ALA4179129 | F | Increase in ATP level in human Friedreich's ataxia lymphocytes at 0.1 uM incubated for 24 hrs by luminescence based assay | Homo sapiens | 2 | ALA4177577 | cell-based format | Scientific Literature | |
11. | ALA4179130 | F | Increase in ATP level in human Friedreich's ataxia lymphocytes at 0.5 uM incubated for 24 hrs by luminescence based assay | Homo sapiens | 2 | ALA4177577 | cell-based format | Scientific Literature | |
12. | ALA4179131 | A | Reduction in ATP level in human Friedreich's ataxia lymphocytes at 5 uM incubated for 24 hrs by luminescence based assay | Homo sapiens | 2 | ALA4177577 | cell-based format | Scientific Literature | |
13. | ALA4260032 | F | Effect on frataxin expression in human GM15850 cells at 50 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
14. | ALA4260033 | F | Effect on frataxin expression in human GM16216 cells at 50 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
15. | ALA4260034 | F | Effect on frataxin expression in human GM15850 cells at 250 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
16. | ALA4260035 | F | Effect on frataxin expression in human GM16216 cells at 250 nM after 24 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
17. | ALA4260036 | F | Effect on frataxin expression in human GM15850 cells at 50 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
18. | ALA4260037 | F | Effect on frataxin expression in human GM16216 cells at 50 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
19. | ALA4260038 | F | Effect on frataxin expression in human GM15850 cells at 250 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature | |
20. | ALA4260039 | F | Effect on frataxin expression in human GM16216 cells at 250 nM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4257548 | cell-based format | Scientific Literature |