# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4187427 | B | Inhibition of C-terminal 6-His tagged recombinant Clostridium difficile toxin B catalytic fragment (Met1 to Leu543 residues) assessed as reduction in glucosyltransferase domain UDP-glucose hydrolysis activity using UDP-glucose and ADP Alexa633 tracer incubated fore 3 hrs by fluorescence polarization assay | Clostridioides difficile | 45 | single protein format | Scientific Literature | ||
2. | ALA4187428 | B | Inhibition of Clostridium difficile toxin B transfected in CHO cells assessed as reduction in caspase 3/7 activation pre-incubated for 1 hr before TcdB addition by luminescence based assay1 | Clostridioides difficile | 12 | cell-based format | Scientific Literature | ||
3. | ALA4187429 | B | Inhibition of Clostridium difficile toxin A transfected in CHO cells assessed as reduction in caspase 3/7 activation pre-incubated for 1 hr before TcdA addition by luminescence based assay1 | Clostridioides difficile | 12 | cell-based format | Scientific Literature | ||
4. | ALA4187430 | A | Stability in human liver microsomes assessed as parent compound remaining level incubated for 15 mins | Homo sapiens | 12 | microsome format | Scientific Literature | ||
5. | ALA4187431 | A | Stability in mouse liver microsomes assessed as parent compound remaining level incubated for 15 mins | Mus musculus | 12 | microsome format | Scientific Literature | ||
6. | ALA4187432 | F | Effect on growth of Clostridium difficile at 0.5 to 100 uM incubated for 24 hrs under anaerobic conditions by spectrophotometry | Clostridioides difficile | 45 | organism-based format | Scientific Literature | ||
7. | ALA4187433 | A | Effect on growth of Lactobacillus reuteri at 0.5 to 100 uM incubated for 24 hrs under anaerobic conditions by spectrophotometry | Limosilactobacillus reuteri | 45 | organism-based format | Scientific Literature | ||
8. | ALA4187434 | A | Effect on growth of Bifidobacterium longum at 0.5 to 100 uM incubated for 24 hrs under anaerobic conditions by spectrophotometry | Bifidobacterium longum | 45 | organism-based format | Scientific Literature | ||
9. | ALA4187435 | A | Effect on growth of Bacteroides fragilis at 0.5 to 100 uM incubated for 48 hrs under anaerobic conditions by spectrophotometry | Bacteroides fragilis | 45 | organism-based format | Scientific Literature | ||
10. | ALA4187436 | A | Clearance in CD1 mouse at 1 mg/kg, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
11. | ALA4187437 | A | Elimination half life in CD1 mouse at 1 mg/kg, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
12. | ALA4187438 | A | Apparent volume of distribution in CD1 mouse at 1 mg/kg, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
13. | ALA4187439 | A | AUC (0 to 24 hrs) in CD1 mouse at 1 mg/kg, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
14. | ALA4187440 | A | AUC (0 to 24 hrs) in CD1 mouse at 10 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
15. | ALA4187441 | A | Cmax in CD1 mouse at 1 mg/kg, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
16. | ALA4187442 | A | Cmax in CD1 mouse at 10 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA4187443 | A | Tmax in CD1 mouse at 10 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
18. | ALA4187444 | A | Stability in mouse plasma assessed as parent compound remaining measured after 15 mins post dose | Mus musculus | 1 | cell-free format | Scientific Literature | ||
19. | ALA4187445 | A | Stability in mouse plasma assessed as parent compound remaining measured after 2 hrs post dose | Mus musculus | 1 | cell-free format | Scientific Literature | ||
20. | ALA4328866 | A | Metabolic stability in mouse plasma assessed as parent compound remaining after 2 hrs | Mus musculus | 2 | cell-free format | Scientific Literature |