| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4179998 | F | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigote infected in monkey LLC-MK2 cells assessed as inhibition of cell invasion by trypanosoma by measuring infected fibroblast at 250 uM pretreated with cells for 30 mins followed by trypomastigote infection measured after 18 hrs by panoptic dye-based optical microscopic analysis (Rvb = 63%) | Trypanosoma cruzi | 7 | ALA4177604 | organism-based format | Scientific Literature | |
| 2. | ALA4179999 | F | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigote infected in monkey LLC-MK2 cells assessed as inhibition of cell invasion by trypanosoma by measuring mean number of amastigote parasites per cells at 250 uM pretreated with cells for 30 mins followed by trypomastigote infection measured after 18 hrs by panoptic dye-based optical microscopic analysis | Trypanosoma cruzi | 7 | ALA4177604 | organism-based format | Scientific Literature | |
| 3. | ALA4180000 | F | Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigote infected in monkey LLCMK2 cells assessed as inhibition of cell invasion by trypanosoma by measuring infection index at 250 uM pretreated with cells for 30 mins followed by trypomastigote infection measured after 18 hrs by panoptic dye-based optical microscopic analysis (Rvb = 68 No_unit) | Trypanosoma cruzi | 7 | ALA4177604 | organism-based format | Scientific Literature | |
| 4. | ALA4180001 | A | Cytotoxicity against monkey LLC-MK2 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Macaca mulatta | 7 | ALA4177604 | cell-based format | Scientific Literature | |
| 5. | ALA4180002 | F | Trypanocidal activity against Trypanosoma cruzi Y trypomastigote assessed as effect on parasite viability at 31.25 to 250 uM after 48 hrs by resazurin-based assay | Trypanosoma cruzi | 7 | ALA4177604 | organism-based format | Scientific Literature | |
| 6. | ALA4180003 | B | Inhibition of recombinant His-tagged Trypanosoma cruzi trans-sialidase N-terminal catalytic domain at 1 mM preincubated for 10 mins followed by MuNANA addition measured over 5 mins by fluorimetric assay relative to control | Trypanosoma cruzi | 7 | ALA4177604 | single protein format | Scientific Literature |
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