| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4198087 | B | Inhibition of recombinant Leishmania infantum trypanothione reductase using T[S]2 as substrate preincubated for 5 mins followed by substrate and NADPH addition measured for 1 hr | Leishmania infantum | 5 | single protein format | Scientific Literature | ||
| 2. | ALA4198089 | B | Activation of recombinant human glutathione reductase using GSSG as substrate preincubated for 5 mins followed by substrate and NADPH addition | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 3. | ALA4198091 | A | Drug metabolism assessed as Tritirachium album proteinase K-mediated compound degradation by measuring half life at 100 uM measured up to 480 mins by HPLC method | Parengyodontium album | 2 | single protein format | Scientific Literature | ||
| 4. | ALA4198095 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/89/IPZ229/1/89 promastigotes at 25 uM after 24 hrs by propidium iodide staining based fluorescence microscopic analysis | Leishmania infantum | 5 | organism-based format | Scientific Literature | ||
| 5. | ALA4198096 | F | Antileishmanial activity against Leishmania infantum MCAN/ES/89/IPZ229/1/89 axenic amastigotes infected in human THP1 cells at 25 uM after 24 hrs by propidium iodide staining based fluorescence microscopic analysis | Leishmania infantum | 5 | organism-based format | Scientific Literature | ||
| 6. | ALA4198097 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 9.375 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | single protein format | Scientific Literature | ||
| 7. | ALA4198098 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 18.75 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4198099 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 37.5 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | single protein format | Scientific Literature | ||
| 9. | ALA4198100 | B | Inhibition of dimerization of HIS/FLAG tagged Leishmania infantum trypanothione reductase assessed as dimer levels at 75 uM incubated for 16 hrs by ELISA (Rvb = 100%) | Leishmania infantum | 4 | single protein format | Scientific Literature |
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