| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4186119 | B | Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 2. | ALA4186120 | P | Aqueous solubility of the compound in PBS at pH 7.4 at 20 degC after 24 hrs by HPLC analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4186121 | P | Solubility of the compound in propylene glycol/ethanol96 at 30 mg/ml after 24 hrs by UV-spectrometric analysis | 38 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4186122 | P | Stability of the compound in propylene glycol/ethanol96 at 0.1 mg/ml measured up to 3 months by HPLC analysis | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4186123 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM by LC-MS/MS analysis | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 6. | ALA4186124 | A | Half life in human neonatal keratinocytes at 1 uM by LC-MS/MS analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4186125 | T | Photoirritancy factor, ratio of EC50 for human neonatal keratinocytes under dark condition to EC50 for human neonatal keratinocytes under 5 J/cm2 UV light exposure | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 8. | ALA4186126 | T | Genotoxicity in p53-competent human TK6 cells in presence of Sprague-Dawley rat S9 fraction by GADD45alpha GFP reporter assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 9. | ALA4186127 | T | Genotoxicity in p53-competent human TK6 cells in absence of Sprague-Dawley rat S9 fraction by GADD45alpha GFP reporter assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 10. | ALA4186129 | B | Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for 24 hrs by HTRF assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA4186130 | B | Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluorescence assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA4186131 | A | Inhibition of ADAM9 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA4186132 | A | Inhibition of ADAM10 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 14. | ALA4186133 | A | Inhibition of recombinant human MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 10 mins by fluorescence assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 15. | ALA4186134 | A | Inhibition of MMP2 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 16. | ALA4186135 | A | Inhibition of MMP3 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA4186136 | A | Inhibition of MMP7 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA4186137 | A | Inhibition of MMP8 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA4186138 | A | Inhibition of MMP9 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA4186139 | A | Inhibition of MMP12 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature |
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