| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4199724 | F | Antagonist activity at human CRTh2 expressed in HEK cells assessed as inhibition of DK-PGD2-mediated attenuation of forskolin-induced intracellular cAMP accumulation preincubated for 10 mins followed by forskolin stimulation measured after 10 to 60 mins by ELISA based chemiluminescence assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA4199725 | B | Displacement of [3H]PGD2 from human CRTh2 expressed in HEK cell membranes after 60 mins by scintillation counting method | Homo sapiens | 45 | cell-based format | Scientific Literature | ||
| 3. | ALA4199726 | F | Antagonist activity at human CRTh2 expressed in CHOK1 cells assessed as inhibition of PGD2-induced beta-arrestin recruitment incubated for 30 mins followed by PGD2 stimulation measured after 60 mins by PathHunter based chemiluminescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 4. | ALA4199727 | F | Antagonist activity at CRTh2 in human whole blood assessed as inhibition of DK-PGD2-induced eosinophils shape change preincubated for 10 mins followed by DK-PGD2 addition measured after 4 mins by flow cytometry | Homo sapiens | 12 | assay format | Scientific Literature | ||
| 5. | ALA4199729 | A | Intrinsic clearance in rat hepatocytes assessed per million cells | Rattus norvegicus | 7 | cell-based format | Scientific Literature |
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