| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4198407 | B | Binding affinity to Keap1 in human HaCaT cells assessed as induction of NRF2/ARE activation-mediated HO1 expression at 1 to 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4198408 | A | Cell cycle arrest in human HaCaT cells assessed as accumulation at G1/S phase at 10 uM after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4198409 | A | Cytotoxicity against human HaCaT cells assessed as reduction in cell viability by measuring morphological changes at 10 uM after 24 hrs by phase contrast microscopic method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4198410 | A | Induction of apoptosis in human HaCaT cells assessed as increase in cleaved caspase-3 protein expression at 10 uM after 6 to 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4198411 | A | Induction of apoptosis in human HaCaT cells assessed as increase in cleaved PARP protein expression at 10 uM after 6 to 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4198412 | B | Binding affinity to Keap1 in human HaCaT cells harboring ARE-GFP-Luc assessed as induction of ARE-dependent GFP expression by luciferase reporter gene based fluorescent microscopic assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4198413 | B | Binding affinity to Keap1 in human HaCaT cells assessed as induction of NRF2 expression by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4198414 | B | Binding affinity to Keap1 in human HaCaT cells assessed as activation of NRF2 by measuring nuclear translocation of NRF2 at 10 uM after 6 to 12 hrs by immunofluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4198415 | B | Binding affinity to Keap1 in NRF2+/+ MEF assessed as induction of NRF2/ARE activation-mediated HO1 expression at 10 uM after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4198416 | B | Binding affinity to Keap1 in NRF2-/- MEF assessed as induction of HO1 expression at 10 uM after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4198417 | B | Binding affinity to Keap1 in NRF2+/+ MEF assessed as induction of NRF2/ARE activation-mediated HO1 expression at 10 uM up to 8 hrs by RT-PCR method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4198418 | B | Binding affinity to Keap1 in NRF2-/- MEF assessed as induction of NRF2/ARE activation-mediated HO1 expression at 10 uM up to 8 hrs by RT-PCR method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4198421 | B | Binding affinity to Keap1 in human HaCaT cells assessed as induction of NRF2/ARE activation-mediated HO1 expression at 10 uM by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4198424 | A | Cytotoxicity against human HaCaT cells assessed as reduction in cell viability at 10 uM after 24 hrs by MTT method | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 15. | ALA4198425 | F | Upregulation of NRF2 expression in skin lysates of mouse at 10 umole applied topically up to 24 hrs by Western blot analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA4198426 | F | Upregulation of HO-1 expression in skin lysates of mouse at 10 umole applied topically up to 24 hrs by Western blot analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4198427 | F | Upregulation of GCLC expression in skin lysates of mouse at 10 umole applied topically up to 24 hrs by Western blot analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA4198428 | F | Anti-carcinogenic effect in hairless mouse assessed as inhibition of number of DMBA/TPA-induced papilloma formation at 10 umol administered topically 3 times per week up to 10 weeks with TPA starting from 1 week post DMBA treatment | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4198429 | F | Anti-carcinogenic effect in hairless mouse assessed as inhibition of incidence of DMBA/TPA-induced papilloma formation at 10 umol administered topically 3 times per week up to 10 weeks with TPA starting from 1 week post DMBA treatment | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4198430 | F | Anti-carcinogenic effect in hairless mouse assessed as inhibition of DMBA/TPA-induced papilloma growth at 10 umol administered topically 3 times per week up to 10 weeks with TPA starting from 1 week post DMBA treatment by hematoxylin/eosin staining based phase-contrast microscopic method | Mus musculus | 1 | organism-based format | Scientific Literature |
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