| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4202175 | B | Antagonist activity at rat alpha3beta4 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 15 | ALA4196223 | cell-based format | Scientific Literature | |
| 2. | ALA4202177 | B | Antagonist activity at rat alpha6/alpha3beta4 nAChR nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 15 | ALA4196223 | cell-based format | Scientific Literature | |
| 3. | ALA4202178 | B | Antagonist activity at rat alpha6/alpha3beta4 nAChR nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 4 | ALA4196223 | cell-based format | Scientific Literature | |
| 4. | ALA4202179 | B | Selectivity index, ratio of IC50 for antagonist activity at rat alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 15 | ALA4196223 | cell-based format | Scientific Literature | |
| 5. | ALA4202180 | B | Antagonist activity at mouse alpha1beta1deltaepsilon nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Mus musculus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 6. | ALA4202181 | B | Antagonist activity at rat alpha2beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 7. | ALA4202182 | B | Antagonist activity at rat alpha2beta4 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 8. | ALA4202183 | B | Antagonist activity at rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 9. | ALA4202184 | B | Antagonist activity at rat alpha4beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 10. | ALA4202185 | B | Antagonist activity at rat alpha4beta4 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 11. | ALA4202186 | B | Antagonist activity at rat alpha7 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 12. | ALA4202187 | B | Antagonist activity at rat alpha9alpha10 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 13. | ALA4202188 | B | Antagonist activity at mouse alpha1beta1deltaepsilon nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Mus musculus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 14. | ALA4202189 | B | Antagonist activity at rat alpha2beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 15. | ALA4202190 | B | Antagonist activity at rat alpha2beta4 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 16. | ALA4202191 | B | Antagonist activity at rat alpha3beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 17. | ALA4202192 | B | Antagonist activity at rat alpha4beta2 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 18. | ALA4202193 | B | Antagonist activity at rat alpha4beta4 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 19. | ALA4202194 | B | Antagonist activity at rat alpha7 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature | |
| 20. | ALA4202195 | B | Antagonist activity at rat alpha9alpha10 nACHR expressed in Xenopus laevis oocytes assessed as inhibition of acetyl choline-induced membrane currents at 10 uM pre-incubated for 5 mins prior to acetyl choline pulse at -70 mV potential by two-electrode voltage clamp assay | Rattus norvegicus | 1 | ALA4196223 | cell-based format | Scientific Literature |
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