# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4199508 | F | Anti-atherosclerosis activity in ApoE knockout pro-atherogenic western diet-induced Tac mouse carotid artery ligation model of atherosclerosis assessed as reduction in coronary flow reserve at 75 to 150 umol/kg/day mixed with food measured for 3 weeks by doppler echocardiography | Mus musculus | 1 | ALA4196112 | organism-based format | Scientific Literature | |
2. | ALA4199509 | B | Inhibition of sPLA2-10 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 18 | ALA4196112 | single protein format | Scientific Literature | |
3. | ALA4199510 | B | Inhibition of sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 16 | ALA4196112 | single protein format | Scientific Literature | |
4. | ALA4199511 | B | Inhibition of sPLA2-5 (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 15 | ALA4196112 | single protein format | Scientific Literature | |
5. | ALA4199513 | B | Inhibition of sPLA2-5 (unknown origin) at 10 uM using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 4 | ALA4196112 | single protein format | Scientific Literature | |
6. | ALA4199514 | B | Inhibition of recombinant human sPLA2-10 using human HDL as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay | Homo sapiens | 17 | ALA4196112 | single protein format | Scientific Literature | |
7. | ALA4199516 | P | Lipophilicity, log D of compound at pH 7.4 | 3 | ALA4196112 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4199517 | B | Selectivity ratio of IC50 for sPLA2-2A (unknown origin) to IC50 for sPLA2-10 (unknown origin) | Homo sapiens | 3 | ALA4196112 | assay format | Scientific Literature | |
9. | ALA4199518 | B | Selectivity ratio of IC50 for sPLA2-5 (unknown origin) to IC50 for sPLA2-10 (unknown origin) | Homo sapiens | 2 | ALA4196112 | assay format | Scientific Literature | |
10. | ALA4199519 | A | Unbound clearance in C57Bl/6J mouse administered iv or po | Mus musculus | 12 | ALA4196112 | organism-based format | Scientific Literature | |
11. | ALA4199520 | B | Inhibition of mouse sPLA2-10 | Mus musculus | 1 | ALA4196112 | single protein format | Scientific Literature | |
12. | ALA4199521 | P | Solubility of the compound in DMSO/HBSS solution at pH 7.4 after 24 hrs by LC-UV/MS analysis | 1 | ALA4196112 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4199522 | A | Apparent permeability in human Caco2 cells | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
14. | ALA4199523 | A | Efflux ratio of apparent permeability in human Caco2 cells from apical to basolateral side | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
15. | ALA4199524 | B | Inhibition of human ERG expressed in CHO cells by ionworks patch clamp assay | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
16. | ALA4199525 | A | Half life in human hepatocytes | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
17. | ALA4199526 | B | Inhibition of human Nav1.5 expressed in CHO cells by ionworks patch clamp assay | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
18. | ALA4199527 | B | Inhibition of human Iks expressed in CHO cells by ionworks patch clamp assay | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
19. | ALA4199528 | B | Inhibition of human Kv4.3 expressed in CHO cells by ionworks patch clamp assay | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature | |
20. | ALA4199529 | B | Inhibition of human Cav3.2 expressed in CHO cells by ionworks patch clamp assay | Homo sapiens | 1 | ALA4196112 | cell-based format | Scientific Literature |