# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4187607 | B | Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 50 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry | Homo sapiens | 36 | ALA4184220 | single protein format | Scientific Literature | |
2. | ALA4187608 | B | Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release at 20 uM pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 67 nM enzyme and chromogenic substrate S-2288 by spectrophotometry | Homo sapiens | 36 | ALA4184220 | single protein format | Scientific Literature | |
3. | ALA4187611 | A | Cmax in Wistar rat at 50 mg/kg, po administered as single dose measured after 1 to 24 hrs by reverse-phase HPLC method | Rattus norvegicus | 19 | ALA4184220 | organism-based format | Scientific Literature | |
4. | ALA4187612 | A | Tmax in Wistar rat at 50 mg/kg, po administered as single dose measured after 1 to 24 hrs by reverse-phase HPLC method | Rattus norvegicus | 19 | ALA4184220 | organism-based format | Scientific Literature | |
5. | ALA4187613 | A | Half life in Wistar rat at 50 mg/kg, po administered as single dose measured after 1 to 24 hrs by reverse-phase HPLC method | Rattus norvegicus | 19 | ALA4184220 | organism-based format | Scientific Literature | |
6. | ALA4187619 | B | Inhibition of human PAI-1 assessed as remaining enzyme activity by measuring p-nitroaniline release pre-incubated for 15 mins before 9.8 nM human tPA substrate addition for 15 mins using 24.5 nM enzyme and chromogenic substrate S-2288 by spectrophotometry | Homo sapiens | 1 | ALA4184220 | single protein format | Scientific Literature |