# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4201511 | B | Binding affinity to BTN3A1 in human PBMC assessed as stimulation of Vgamma9 Vdelta2 T cells incubated for 3 days and measured after 11 days post compound removal by flow cytometry | Homo sapiens | 13 | assay format | Scientific Literature | ||
2. | ALA4201513 | A | Stability in 50% pooled human plasma assessed as fraction of compound remaining at 100 uM after 2 hrs by LC-MS method relative to control | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
3. | ALA4201514 | A | Stability in 50% pooled human plasma assessed as fraction of compound remaining at 100 uM after 24 hrs by LC-MS method relative to control | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
4. | ALA4201515 | A | Stability in 50% pooled human plasma assessed as half life at 100 uM by LC-MS method | Homo sapiens | 10 | cell-free format | Scientific Literature | ||
5. | ALA4201516 | B | Binding affinity to BTN3A1 in human PBMC assessed as stimulation of Vgamma9 Vdelta2 T cells at 100 nM incubated for 3 days and measured after 11 days post compound removal by flow cytometry | Homo sapiens | 11 | assay format | Scientific Literature | ||
6. | ALA4201517 | B | Binding affinity to BTN3A1 in human PBMC assessed as stimulation of Vgamma9 Vdelta2 T cells at 100 nM incubated for 3 days and measured after 11 days post compound removal by flow cytometry relative to sodium (E)-5-hydroxy-4-methylpent-3-enylphosphonate | Homo sapiens | 10 | assay format | Scientific Literature | ||
7. | ALA4201518 | B | Binding affinity to BTN3A1 in human PBMC assessed as stimulation of Vgamma9 Vdelta2 T cells at 100 nM incubated for 3 days and measured after 11 days post compound removal by flow cytometry relative to (E)-dimethyl 5-hydroxy-4-methylpent-3-enylphosphonate | Homo sapiens | 9 | assay format | Scientific Literature | ||
8. | ALA4201519 | A | Cytotoxicity in human K562 cells assessed as reduction in cell viability incubated for 72 hrs by cell-QB reagent based assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
9. | ALA4201520 | B | Binding affinity to BTN3A1 in human Vgamma9 Vdelta2 T cells mixed with human K562 cells pretreated with compound for 4 hrs assessed as INF-gamma production measured after 20 hrs by ELISA | Homo sapiens | 9 | assay format | Scientific Literature |