| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4202266 | B | Displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs by fluorescence polarization assay | Homo sapiens | 28 | assay format | Scientific Literature | ||
| 2. | ALA4202267 | B | Displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) measured after 3 hrs by fluorescence polarization assay | Homo sapiens | 28 | assay format | Scientific Literature | ||
| 3. | ALA4202270 | B | Ratio of Ki for displacement of N-Flu-DOT1L from MBP-tagged ENL (unknown origin) (489 to 559 residues) expressed in Escherichia coli BL21(DE3) to Ki for displacement of N-Flu-DOT1L from MBP-tagged AF9 (unknown origin) (487 to 568 residues) expressed in Escherichia coli BL21(DE3) | Homo sapiens | 27 | assay format | Scientific Literature | ||
| 4. | ALA4202272 | B | Displacement of (S)-N-((S)-1-((S)-3-amino-1-((S)-3-cyclopentyl-1-((S)-2-((S)-1-(dimethylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-((S)-4-methyl-2-(6-(5-((3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)pentanoyl)pyrrolidine-2-carboxamide from Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells measured after overnight incubation by pull down assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4202273 | B | Displacement of (S)-N-((S)-1-((S)-3-amino-1-((S)-3-cyclopentyl-1-((S)-2-((S)-1-(dimethylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-((S)-4-methyl-2-(6-(5-((3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)pentanoyl)pyrrolidine-2-carboxamide from Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 100 nM measured after overnight incubation by pull down assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4202274 | B | Displacement of (S)-N-((S)-1-((S)-3-amino-1-((S)-3-cyclopentyl-1-((S)-2-((S)-1-(dimethylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-((S)-4-methyl-2-(6-(5-((3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)pentanoyl)pyrrolidine-2-carboxamide from Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 0.3 uM measured after overnight incubation by pull down assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4202275 | B | Displacement of (S)-N-((S)-1-((S)-3-amino-1-((S)-3-cyclopentyl-1-((S)-2-((S)-1-(dimethylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-((S)-4-methyl-2-(6-(5-((3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)pentanoyl)pyrrolidine-2-carboxamide from Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 1 uM measured after overnight incubation by pull down assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4202276 | B | Displacement of (S)-N-((S)-1-((S)-3-amino-1-((S)-3-cyclopentyl-1-((S)-2-((S)-1-(dimethylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-((S)-4-methyl-2-(6-(5-((3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)pentanoyl)pyrrolidine-2-carboxamide from Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 3 uM measured after overnight incubation by pull down assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4202277 | B | Inhibition of FLAG-tagged DOT1L binding to Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells measured after overnight incubation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4202278 | B | Inhibition of FLAG-tagged DOT1L binding to Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 0.3 uM measured after overnight incubation by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4202279 | B | Inhibition of FLAG-tagged DOT1L binding to Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 1 uM measured after overnight incubation by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4202280 | B | Inhibition of FLAG-tagged DOT1L binding to Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 3 uM measured after overnight incubation by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4202281 | B | Inhibition of FLAG-tagged DOT1L binding to Myc-tagged AF9 CxxC domain (unknown origin) expressed in HEK293T cells at 10 uM measured after overnight incubation by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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