# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4195900 | B | Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measuring reduction in [3H]thymidine incorporation preincubated for 5 days followed by [3H]thymidine addition measured after 18 hrs by liquid scintillation counting method | Homo sapiens | 42 | assay format | Scientific Literature | ||
2. | ALA4195901 | B | Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 mins by ADP-Glo assay | Homo sapiens | 41 | assay format | Scientific Literature | ||
3. | ALA4195904 | A | Intrinsic clearance in human liver microsomes at 3 uM up to 45 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 8 | microsome format | Scientific Literature | ||
4. | ALA4195905 | A | Intrinsic clearance in mouse liver microsomes at 3 uM up to 45 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 8 | microsome format | Scientific Literature | ||
5. | ALA4195906 | B | Inhibition of human ERG by cell based automated patch clamp method | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
6. | ALA4195907 | A | Inhibition of CYP3A4 in human liver microsomes assessed as decrease in midazolam 1-hydroxylation by LC-MS/MS analysis | Homo sapiens | 20 | microsome format | Scientific Literature | ||
7. | ALA4195908 | P | Lipophilicity, log D of the compound in pH 7.4 phosphate buffer after 90 mins by LC-MS analysis | 26 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4195909 | P | Kinetic solubility of the compound in pH 7.4 solution up to 350 uM after 90 mins | 36 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA4195910 | B | Selectivity ratio of IC50 for recombinant human GST-tagged PI3KC2gamma (468 to 1203 residues) expressed in insect cells to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4195911 | B | Selectivity ratio of IC50 for recombinant human GST-tagged PI3KC2alpha catalytic domain expressed in baculovirus expression system to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 1 | assay format | Scientific Literature | ||
11. | ALA4195912 | B | Selectivity ratio of IC50 for recombinant human GST-tagged PI3KC2beta catalytic domain expressed in baculovirus expression system to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 1 | assay format | Scientific Literature | ||
12. | ALA4195913 | B | Inhibition of recombinant human full length GST-tagged PI4K2alpha expressed in insect cells at 10 uM | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4195914 | B | Inhibition of recombinant human full length GST-tagged PI4K2beta expressed in insect cells at 10 uM | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4195915 | B | Inhibition of PI4K3alpha (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
15. | ALA4195916 | B | Selectivity ratio of IC50 for human full length His-tagged PI3K p110alpha/p85 alpha expressed in baculovirus expression system to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 2 | assay format | Scientific Literature | ||
16. | ALA4195917 | B | Selectivity ratio of IC50 for recombinant human full length His-tagged p110 beta/p85 beta to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 2 | assay format | Scientific Literature | ||
17. | ALA4195918 | B | Selectivity ratio of IC50 for recombinant human full length His-tagged PI3Kgamma to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 2 | assay format | Scientific Literature | ||
18. | ALA4195919 | B | Selectivity ratio of IC50 for recombinant human full length His-tagged p110delta/p85alpha to IC50 for recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system | Homo sapiens | 2 | assay format | Scientific Literature | ||
19. | ALA4195920 | P | Thermodynamic solubility of the compound in pH 7.4 solution after 90 mins by UVLC-MS analysis | 16 | small-molecule physicochemical format | Scientific Literature | |||
20. | ALA4195921 | A | Efflux ratio of apparent permeability in human Caco2 cells at 10 uM after 2 hrs by LC-MS/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature |